Evidence map›Paper›PMID 28054255›Full record

SynthesisJournal of cancer survivorship : research and practice2017

Evaluation of resistance training to improve muscular strength and body composition in cancer patients undergoing neoadjuvant and adjuvant therapy: a meta-analysis.

Camila S Padilha, Poliana Camila Marinello, Daniel A Galvão, Robert U Newton, Fernando H Borges, Fernando Frajacomo, Rafael Deminice

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of cancer survivorship : research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 12 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05878106 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study)

TypeinterventionalSponsorUniversity of DeustoRan2024 to 2025Enrolled120ConditionsBreast Cancer, Supplementation, Resistance Training, Physical PerformanceArmsCreatine supplementation, Resistance training
NCT07484776 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer and the Possible Effect of a Physical Exercise Intervention

TypeinterventionalSponsorUniversidad Europea de MadridRan2026 to 2028Enrolled40ConditionsTriple-Negative Breast Cancer (TNBC)ArmsCardiovascular training at maximal fat oxidation (FATmax), Cardiovascular training at maximal aerobic power (MAP), Resistance training
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 12 syntheses or guidelines pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024
    Pooled it
  4. Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  11. Guideline
  12. Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  13. Trial
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  20. Endurance and resistance training in patients with acute leukemia undergoing induction chemotherapy-a randomized pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Trial

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Camila S PadilhaDepartment of Physical Education, Faculty of Physical Education and Sport, State University of Londrina, Londrina, PR, Brazil. camilapersonal@yahoo.com.br.
Poliana Camila MarinelloMolecular Pathology Laboratory, Department of Pathology Science, State University of Londrina, Londrina, PR, Brazil.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
Fernando H BorgesLaboratory Pathophysiology and Free Radical, Department of Pathology Science, State University of Londrina, Londrina, PR, Brazil.
Fernando FrajacomoProgram of Molecular Carcinogenesis, Brazilian National Institute of Cancer (INCA), Rio de Janeiro, Brazil.
Rafael DeminiceDepartment of Physical Education, Faculty of Physical Education and Sport, State University of Londrina, Londrina, PR, Brazil.
Universidade Estadual de Londrina · BREdith Cowan University · AUInstituto Nacional do Câncer · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMuscle atrophy and strength decline are two of the most prominent characteristics in cancer patients undergoing cancer therapy, leading to decreased functional ability and reduced quality of life. Therefore, the aim is to systematically review research evidence of the effects of resistance exercise (RE) on lower-limb muscular strength, lean body mass (LBM), and body fat (BF) in cancer patients undertaking neoadjuvant or adjuvant therapy.

methodsThis research was conducted using the following online database: Clinical Trial Register, Cochrane Trial Register, PubMed, SPORT Discus, and SciELO, from September 2014 until May 2015. We used the following keywords in various combinations with a systematic search: "Cancer therapy," "Wasting muscle," "Muscle loss," "Muscle function," "Neoadjuvant therapy," "Adjuvant thera-py," "Resistance Training," "Weight training," and "Exercise." After selection of 272 full-text articles, 14 publications were included in this meta-analysis.

resultsResistance exercise (RE) during neoadjuvant or adjuvant therapy increased lower-limb muscular strength (mean: 26.22 kg, 95% CI [16.01, 36.43], heterogeneity: P = <0.01, I

conclusionRE is effective to increase lower-limb muscular strength, increase LBM, and decrease BF in cancer patients undergoing neoadjuvant and adjuvant therapy regardless of the kind of treatment. IMPLICATIONS FOR CANCER SURVIVORS: RE increases muscle strength, maintains LBM, and reduces BF in cancer patients undergoing adjuvant and neoadjuvant therapies. Cancer patients and survivors should consider undertaking RE as an effective countermeasure for treatment-related adverse effects to the musculoskeletal system.

Indexed as

Body CompositionFemaleHumansMaleMuscle StrengthNeoadjuvant TherapyNeoplasmsResistance TrainingBody fatCancer treatmentResistance exerciseSkeletal muscle

Identifiers

PMID28054255
OpenAlexW2570713262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.