ReviewJournal of neural transmission (Vienna, Austria : 1996)2018
Personality as an intermediate phenotype for genetic dissection of alcohol use disorder.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Comprehensive meta-analysis of associations between temperament and character traits in Cloninger's psychobiological theory and mental disorders.The Journal of international medical research · 2022Pooled it
- The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids.Scientific reports · 2025Article
- Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder.Cells · 2025Article
- The role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Association Study of Serotonin 1A Receptor Gene, Personality, and Anxiety in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024Article
- MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Personality subtypes in adults with social anxiety disorder - novelty seeking makes the difference.BMC psychiatry · 2022Article
- Dual Diagnosis in Adolescents with Problematic Use of Video Games: Beyond Substances.Brain sciences · 2022Article
- Do Individuals with Internet Gaming Disorder Share Personality Traits with Substance-Dependent Individuals?International journal of environmental research and public health · 2022Article
- Serotonin ReceptorInternational journal of environmental research and public health · 2022Article
- The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.Scientific reports · 2022Article
- Association between platelet MAO activity and lifetime drug use in a longitudinal birth cohort study.Psychopharmacology · 2022Article
- Personality-Related Factors and Depressive Symptomatology Predict Behavioral Control in Patients With Alcohol Use Disorders.Frontiers in psychiatry · 2022Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Risk and resilience for alcohol use disorder revealed in brain functional connectivity.NeuroImage. Clinical · 2021Article
- Neonatal temperament and neuromotor differences are predictive of adolescent alcohol intake in rhesus monkeys (Macaca mulatta).American journal of primatology · 2020Article
- Big Five personality traits and alcohol, nicotine, cannabis, and gambling disorder comorbidity.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Biosignature Discovery for Substance Use Disorders Using Statistical Learning.Trends in molecular medicine · 2018Review
- Personality Traits Related to Binge Drinking: A Systematic Review.Frontiers in psychiatry · 2017Review
- An observational study on deliberate self-harm in individuals with alcohol dependence syndrome.Industrial psychiatry journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic and environmental interactive influences on predisposition to develop alcohol use disorder (AUD) account for the high heterogeneity among AUD patients and make research on the risk and resiliency factors complicated. Several attempts have been made to identify the genetic basis of AUD; however, only few genetic polymorphisms have consistently been associated with AUD. Intermediate phenotypes are expected to be in-between proxies of basic neuronal biological processes and nosological symptoms of AUD. Personality is likely to be a top candidate intermediate phenotype for the dissection of the genetic underpinnings of different subtypes of AUD. To date, 38 studies have investigated personality traits, commonly assessed by the Cloninger's Tridimensional Personality Questionnaire (TPQ) or Temperament and Character Inventory (TCI), in relation to polymorphisms of candidate genes of neurotransmitter systems in alcohol-dependent patients. Particular attention has been given to the functional polymorphism of the serotonin transporter gene (5-HTTLPR), however, leading to contradictory results, whereas results with polymorphisms in other candidate monoaminergic genes (e.g., tryptophan hydroxylase, serotonin receptors, monoamine oxidases, dopamine receptors and transporter) are sparse. Only one genome-wide association study has been performed so far and identified the ABLIM1 gene of relevance for novelty seeking, harm avoidance and reward dependence in alcohol-dependent patients. Studies investigating genetic factors together with personality could help to define more homogenous subgroups of AUD patients and facilitate treatment strategies. This review also urges the scientific community to combine genetic data with psychobiological and environmental data to further dissect the link between personality and AUD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.