ArticleJournal of traditional and complementary medicine2017
Yokukansan enhances the proliferation of B65 neuroblastoma.
Article in Journal of traditional and complementary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells.Journal of natural medicines · 2024Article
- Influence of Yokukansan on the refractive index of neuroblastoma cells.Biomedical optics express · 2023Article
- Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids inFrontiers in pharmacology · 2021Review
- Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder.BioMed research international · 2021Article
- Beta-Boswellic Acid and Ethanolic Extract of Olibanum Regulating the Expression Levels ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Sansoninto as evidence-based remedial medicine for depression-like behavior.Journal of natural medicines · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Yokukansan, a traditional Japanese herbal medicine, has been considered to be a novel alternative treatment for several neurological diseases such as neurodegenerative disorders, as well as neurosis, insomnia, and behavioral and psychological symptoms in Alzheimer's disease. Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. Recently, several studies have shown that yokukansan has a neuroprotective effect. In this study, we focused on whether or no yokukansan influences cell proliferation related to cell-cycle progression by using B65 neuroblastoma cells derived from monoaminergic neurons. Under treatment with yokukansan, the proliferation rate of B65 neuroblastoma cells significantly increased in a dose-dependent manner. In particular, a proliferative effect was observed after treatment with yokukansan for 48 h and 72 h. Moreover, among seven medicinal herbs that comprise yokukansan, both
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