ArticleBBA clinical2017
Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma.
Article in BBA clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment.Oxidative medicine and cellular longevity · 2020Pooled it
- Metabolomic Insights into Head and Neck Cancer: Recent Advances and Future Directions.Current oncology (Toronto, Ont.) · 2026Review
- 2-Hydroxyglutarate in onco-pathway: a metabolic driver of proto-oncogene activation.Frontiers in oncology · 2026Review
- The role of salivary metabolomics in chronic periodontitis: bridging oral and systemic diseases.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Development of an expert system for the classification of myalgic encephalomyelitis/chronic fatigue syndrome.PeerJ. Computer science · 2024Article
- Metabolic Patterns of High-Invasive and Low-Invasive Oral Squamous Cell Carcinoma Cells Using Quantitative Metabolomics andBiomolecules · 2023Article
- Differences in the metabolomic profile of the human palatine tonsil between pediatrics and adults.PloS one · 2023Article
- Developing a Method to Estimate the Downstream Metabolite Signals from Hyperpolarized [1-Sensors (Basel, Switzerland) · 2022Article
- Current and Future Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma.Current oncology (Toronto, Ont.) · 2022Review
- Application of liquid biopsy as multi-functional biomarkers in head and neck cancer.British journal of cancer · 2022Review
- Identification of Possible Salivary Metabolic Biomarkers and Altered Metabolic Pathways in South American Patients Diagnosed with Oral Squamous Cell Carcinoma.Metabolites · 2021Article
- Oncometabolite L-2-hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma.International journal of cancer · 2021Article
- Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts.Cancers · 2021Article
- Metabolomics of Oral/Head and Neck Cancer.Advances in experimental medicine and biology · 2021Article
- Oncometabolites in renal cancer.Nature reviews. Nephrology · 2020Review
- Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function.Metabolites · 2020Review
- Hypoxic Transformation of Immune Cell Metabolism Within the Microenvironment of Oral Cancers.Frontiers in oral health · 2020Review
- Prognostic Role of Serum Amino Acids in Head and Neck Cancer.Disease markers · 2020Article
- Metabolomics study of oral cancers.Metabolomics : Official journal of the Metabolomic Society · 2019Review
- The Microbiome of Temporal Arteries.Pathogens & immunity · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMetabolomics represents a promising approach for discovering novel targets and biomarkers in head and neck squamous cell carcinoma (HNSCC). Here we used metabolomics to identify oral metabolites associated with HNSCC.
methodsTumor and adjacent normal tissue from surgical resections and presurgical oral washes as well as oral washes were collected from healthy participants. Metabolites extractions of these samples were analyzed by liquid chromatography-mass spectroscopy (LC/MS), LC/MS/MS and gas chromatography-MS (GC/MS).
resultsAmong 28 samples obtained from 7 HNSCC cases and 7 controls, 422 metabolites were detected (269 identified and 153 unidentified). Oral washes contained 12 and 23 metabolites in healthy controls and HNSCC patients, respectively, with phosphate and lactate being the most abundant. Small molecules related to energy metabolism were significantly elevated in HNSCC patients compared to controls. Levels of beta-alanine, alpha-hydroxyisovalerate, tryptophan, and hexanoylcarnitine were elevated in HNSCC oral washes compared to healthy controls (range 7.8-12.2-fold). Resection tissues contained 22 metabolites, of which eight were overproduced in tumor by 1.9- to 12-fold compared to controls. TCA cycle analogs 2-hydroxyglutarate
conclusionsOral metabolites related to energy metabolism were elevated in HNSCC, and acylcarnitine and 2HG may have potential as non-invasive biomarkers. Further validation in clinical studies is warranted.
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