ReviewThe journal of the American College of Clinical Wound Specialists2015
Novel Insights on Understanding of Keloid Scar: Article Review.
Review in The journal of the American College of Clinical Wound Specialists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- A multi-dataset single-cell meta-analysis of human keloid skin across Asian, Black and White populations reveals endothelial and mesenchymal programs linked to ethnic disparities.Frontiers in medicine · 2026Pooled it
- Recent advances on anti-scarring properties of amniotic membrane: emerging strategies and clinical potentials in regenerative medicine.Stem cell research & therapy · 2026Review
- Racial and Skin Tone Differences in Scar Maturation: A Prospective Analysis of Aesthetic and Physiological Outcomes Using the Modified POSAS Scale.International wound journal · 2026Observational
- Article
- piR-hsa-022095 Drives Hypertrophic Scar Formation via KLF11-Dependent Fibroblast Proliferation.Biomedicines · 2025Article
- Scoping review for pain mitigation during intralesional injections of corticosteroid for hypertrophic scar and keloid treatment.BMJ open · 2025Article
- ERG transcriptionally activates SFRP1 to promote apoptosis of keloid fibroblasts and inhibit epithelial-mesenchymal transition and fibrosis through the Wnt3a/β-catenin pathway.Archives of dermatological research · 2025Article
- PTB Regulates Keloid Fibroblast Migration and Proliferation Through Autophagy.Aesthetic plastic surgery · 2025Article
- Network Pharmacology, Molecular Docking Analysis and Experiment Validations on Molecular Targets and Mechanisms of the Dispel-Scar Ointment in Scar Treatment.Combinatorial chemistry & high throughput screening · 2025Article
- Biopsychosocial impact of keloids on quality of life.JAAD reviews · 2024Article
- Enhanced bioenergetic cellular activity with metabolic switch to aerobic glycolysis in Keloid and Folliculitis Keloidalis Nuchae.Archives of dermatological research · 2024Article
- Compression Therapy for Keloid Scars: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Scarring Skin: Mechanisms and Therapies.International journal of molecular sciences · 2024Review
- Long Non-Coding RNA B3GALT5-AS1 Suppresses Keloid Progression by Regulating the β-Trcp1-Mediated Ubiquitination of HuR.Clinical, cosmetic and investigational dermatology · 2024Article
- Comprehensive Analysis of Current Treatment Approaches for Keloids in Pediatrics: A Systematic Review.Cureus · 2023Review
- Defining a Unique Gene Expression Profile in Mature and Developing Keloids.JID innovations : skin science from molecules to population health · 2023Article
- Impaired healing of cutaneous wound in a Trpv1 deficient mouse.Experimental animals · 2023Article
- Extracellular vesicles from Lactobacillus druckerii inhibit hypertrophic scar fibrosis.Journal of nanobiotechnology · 2023Article
- Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review.Journal of cellular and molecular medicine · 2023Review
- Vascular and Collagen Target: A Rational Approach to Hypertrophic Scar Management.Advances in wound care · 2023Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keloid scar, dermal benign fibro-proliferative growth that extends outside the original wound and invades adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempts were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars include combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment. In this review, PubMed, clinical key and Wright State Library web site have been used to investigate any update regarding Keloid disease. We used Keloid, scar formation, hypertrophic scar and collagen as key words. More than 40 articles have been reviewed. This paper reviews literature about keloid scar formation mechanism, the most recent therapeutic options including the ones under research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.