SynthesisNeuroImage. Clinical2017
Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke.
Synthesis in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prognostic accuracy of transcranial magnetic stimulation-induced motor evoked potentials on recovery of upper limb: a systematic review.Frontiers in neurologyPooled it
- Multisensory BCI promotes motor recovery via high-order network-mediated interhemispheric integration in chronic stroke.BMC medicine · 2025Trial
- Repetitive reaching training combined with transcranial Random Noise Stimulation in stroke survivors with chronic and severe arm paresis is feasible: a pilot, triple-blind, randomised case series.Journal of neuroengineering and rehabilitation · 2017Trial
- How deep is your recovery? Rethinking true motor recovery versus compensation in neurorehabilitation.International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation · 2026Review
- A structural causal model for robot-assisted upper-limb neurorehabilitation.Frontiers in rehabilitation sciences · 2026Article
- Functional connectivity associated with severe upper limb impairment in resting-state electroencephalography among chronic stroke survivors: a machine learning approach.Journal of neuroengineering and rehabilitation · 2025Article
- Adaptive Compensatory Neurophysiological Biomarkers of Motor Recovery Post-Stroke: Electroencephalography and Transcranial Magnetic Stimulation Insights from the DEFINE Cohort Study.Brain sciences · 2024Article
- Corticospinal Tract Sparing in Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Modulation of the Association Between Corticospinal Tract Damage and Outcome After Stroke by White Matter Hyperintensities.Neurology · 2024Article
- External Validation of a Dynamic Prediction Model for Upper Limb Function After Stroke.Archives of rehabilitation research and clinical translation · 2024Article
- Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke.Brain communications · 2024Article
- White matter hyperintensities modify relationships between corticospinal tract damage and motor outcomes after stroke.medRxiv : the preprint server for health sciences · 2023Article
- Prediction of rehabilitation induced motor recovery after stroke using a multi-dimensional and multi-modal approach.Frontiers in aging neuroscience · 2023Article
- Cortical N-acetylaspartate concentrations are impacted in chronic stroke but do not relate to motor impairment: A magnetic resonance spectroscopy study.Human brain mapping · 2021Article
- Article
- Poststroke Impairment and Recovery Are Predicted by Task-Specific Regionalization of Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Observational
- Infarct topography and functional outcomes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable.International journal of stroke : official journal of the International Stroke Society · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
To build an understanding of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke, we conducted a pooled individual data systematic review to: 1) characterize brain biomarkers; 2) determine relationship(s) between biomarkers and motor outcome; and 3) establish relationship(s) between biomarkers and motor recovery. Three electronic databases were searched up to October 2, 2015. Eligible studies included adults with severe arm impairment after stroke. Descriptive statistics were calculated to characterize brain biomarkers, and pooling of individual patient data was performed using mixed-effects linear regression to examine relationships between brain biomarkers and motor outcome and recovery. Thirty-eight articles including individual data from 372 people with severe arm impairment were analysed. The majority of individuals were in the chronic (> 6 months) phase post stroke (51%) and had a subcortical stroke (49%). The presence of a motor evoked potential (indexed by transcranial magnetic stimulation) was the only biomarker related to better motor outcome ( PROSPERO: CRD42015026107.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.