Evidence map›Paper›PMID 28053523›Full record

ArticleInternational journal of nanomedicine

Anti-MUC1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations.

Fagner Santos do Carmo, Eduardo Ricci-Junior, Cristal Cerqueira-Coutinho, Marta de Souza Albernaz, Emerson Soares Bernardes, Sotiris Missailidis, Ralph Santos-Oliveira

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Mucin Glycans: A Target for Cancer Therapy.Molecules (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Contrast media & molecular imaging · 2019
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fagner Santos do CarmoRio de Janeiro State University, Biology Institute Roberto Alcantara Gomes; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute.
Eduardo Ricci-JuniorFederal University of Rio de Janeiro, Faculty of Pharmacy.
Cristal Cerqueira-CoutinhoFederal University of Rio de Janeiro, Institute of Macromolecules Eloisa Mano.
Marta de Souza AlbernazRio de Janeiro State University, Biology Institute Roberto Alcantara Gomes; University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro.
Emerson Soares BernardesInstituto de Pesquisas Energéticas e Nucleares, Centro de Radiofarmácia, São Paulo.
Sotiris MissailidisInstitute of Technology in Immunobiologics Bio-Manguinhos, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute.
Nuclear Engineering Institute · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early and specific detection of tumors remains a barrier in oncology, especially in cases such as the triple-negative breast cancer (TNBC). To address this gap, aptamers have found an important application in the recognition of tumor biomarkers such as mucin 1 (MUC1). However, there are still some difficulties in the use of aptamer, as their rapid biological clearance makes their use as drugs limited. In this study, the anti-MUC1 aptamer was used as a drug delivery system (DDS) for a radioactive polymeric nanoparticle (NP) in the imaging of TNBCs. Thus, poly(lactic-

Indexed as

AnimalsAptamers, PeptideCell Line, TumorDrug Delivery SystemsDynamic Light ScatteringFemaleHumansMice, Inbred BALB CMucin-1NanoparticlesPolymersRadiopharmaceuticalsTechnetiumTissue DistributionTomography, Emission-Computed, Single-PhotonTriple Negative Breast NeoplasmsAptamers, PeptideMUC1 protein, humanMucin-1PolymersRadiopharmaceuticalsTechnetiumaptamercancer controlimagingnuclear medicineradiopharmacy

Identifiers

PMID28053523
PMCPMC5191850
OpenAlexW2565230719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.