ArticleInternational journal of chronic obstructive pulmonary disease2017
Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02627872 (Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Sex differences in adult asthma and COPD therapy: a systematic review.Respiratory research · 2022Pooled it
- Smoking-associated increase in mucins 1 and 4 in human airways.Respiratory research · 2020Trial
- Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype.Respiratory research · 2018Trial
- Sex and Gender in Chronic Obstructive Pulmonary Disease: Does It Matter?Journal of personalized medicine · 2026Review
- Expression Levels of MUC5AC and MUC5B in Airway Goblet Cells Are Associated with Traits of COPD and Progression of Chronic Airflow Limitation.International journal of molecular sciences · 2024Article
- Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females.The Journal of clinical investigation · 2024Article
- SARS-CoV-2 mucosal vaccine protects against clinical disease with sex bias in efficacy.Vaccine · 2024Article
- Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage.Briefings in bioinformatics · 2023Article
- Mucins 3A and 3B Are Expressed in the Epithelium of Human Large Airway.International journal of molecular sciences · 2023Observational
- Contribution of adaptive immunity to human COPD and experimental models of emphysema.Physiological reviews · 2023Review
- Sexual dimorphism in chronic respiratory diseases.Cell & bioscience · 2023Review
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.Respiratory research · 2020Article
- Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy.International journal of chronic obstructive pulmonary disease · 2020Review
- Article
- The Effect of Mouse Strain, Sex, and Carcinogen Dose on Toxicity and the Development of Lung Dysplasia and Squamous Cell Carcinomas in Mice.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD.Chest · 2018Article
- Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD.Respiratory research · 2018Article
- Roles of Myeloid and Lymphoid Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease.Frontiers in immunology · 2018Review
- Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes are believed to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). How T cells are recruited to the lungs and contribute to the inflammatory process is largely unknown. COPD is a heterogeneous disease, and discriminating disease phenotypes based on distinct molecular and cellular pathways may provide new approaches for individualized diagnosis and therapies. Bronchoalveolar lavage (BAL) and blood samples were obtained from 40 never-smokers, 40 smokers with normal lung function, and 38 COPD patients. T-cell chemokine receptor expression was analyzed with flow cytometry, and soluble BAL cytokines and chemokines were measured using a cytokine multiplex assay. Correlations with gender and clinical characteristics including lung imaging were investigated using multivariate modeling. Th1/Tc1- and Th2/Tc2-associated soluble analytes and T-cell chemokine receptors were analyzed as cumulative Th1/Tc1 and Th2/Tc2 immune responses. A higher expression of chemokine receptor CCR5 on CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.