Evidence map›Paper›PMID 28053374›Full record

ArticleJournal of orthopaedics2017

Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors.

Swati Shrestha, Carolyn Meyers, Jia Shen, Paulina Giacomelli, Michelle A Scott, Chia Soo, Sarah M Dry, Kang Ting, Aaron W James

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Swati ShresthaSchool of Dentistry, University of California, Los Angeles, USA.
Carolyn MeyersDepartment of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
Jia ShenSchool of Dentistry, University of California, Los Angeles, USA.
Paulina GiacomelliSchool of Dentistry, University of California, Los Angeles, USA.
Michelle A ScottNationwide Children's Hospital, Columbus, OH, USA.
Chia SooOrthopedic Hospital Research Center, University of California, Los Angeles, USA; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Sarah M DryDepartment of Pathology, The Johns Hopkins University, Baltimore, MD, USA.
Kang TingSchool of Dentistry, University of California, Los Angeles, USA.
Aaron W JamesDepartment of Pathology, The Johns Hopkins University, Baltimore, MD, USA; Orthopedic Hospital Research Center, University of California, Los Angeles, USA.
University of California, Los Angeles · USJohns Hopkins University · USNationwide Children's Hospital · USOrthopaedic Hospital · US

Funding

NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
NIAMS NIH HHS K08 AR068316
6 · The paper itself

Abstract

objectivePerivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance.

methodsHere, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples.

resultsWhile Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance. CONCLUSION/IMPLICATIONS: Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.

Indexed as

AngiomyolipomaAngiopoietinLymphangiomyomaPEComaPericytePerivascular epithelioid cell tumor

Identifiers

PMID28053374
PMCPMC5196089
OpenAlexW2567382321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.