ArticleScientific reports2017
Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities.Bioactive materials · 2025Review
- Periodontal ligament stem cell-based bioactive constructs for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
- The recent advances in scaffolds for integrated periodontal regeneration.Bioactive materials · 2021Review
- Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration.Stem cells international · 2021Review
- Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration.Tissue engineering and regenerative medicine · 2020Article
- Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet.Scientific reports · 2020Article
- Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics.Journal of cell communication and signaling · 2018Review
- The Effect of Smoking Behavior on Alveolar Bone Marrow Mesenchymal Stem Cells of Clinical Implant Patient.BioMed research international · 2018Article
- Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells.International journal of medical sciences · 2018Article
- Advanced smart biomaterials and constructs for hard tissue engineering and regeneration.Bone research · 2018Article
- Evaluation of the periodontal regenerative properties of patterned human periodontal ligament stem cell sheets.Journal of periodontal & implant science · 2017Article
- Electrospun Zein/Gelatin Scaffold-Enhanced Cell Attachment and Growth of Human Periodontal Ligament Stem Cells.Materials (Basel, Switzerland) · 2017Article
- Therapeutic potential of dental stem cells.Journal of tissue engineeringReview
Corrections and comments
- Expression of concern · 2022-08-31Concerns/Issues about Data · Updated to Retraction · Upgrade/Update of Prior Notice(s) ·
- Correction · 2020-05-27Error in Image ·
- Retraction · 2023-06-20Duplication of/in Image · Unreliable Results and/or Conclusions · Upgrade/Update of Prior Notice(s) ·
- Erratum issued
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface. Importantly, the compound CAs of PDLSCs and JBMSCs regenerated periodontal ligament-like fibers and mineralized matrix on the Ti scaffold surface, both in nude mice ectopic and minipig orthotopic transplantations. Our data revealed that an effective regenerative microenvironment, reconstructed by JBMSCs, promoted periodontium regeneration by regulating PDLSCs function on the Ti material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.