ArticleOncotarget2017
Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- The role of hypoxic microenvironment in rheumatoid arthritis.Frontiers in immunology · 2025Review
- RND1 Induces Ferroptosis to Alleviate Inflammatory Response, Proliferation, Invasion, and Migration of Rheumatoid Synoviocytes.Journal of inflammation research · 2025Article
- Autophagy pathways in autoimmune diseases.Journal of autoimmunity · 2023Review
- Effects of Prunus Tomentosa Thumb Total Flavones on adjuvant arthritis in rats and regulation of autophagy.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023Article
- Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis.Antioxidants (Basel, Switzerland) · 2022Review
- Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review.Frontiers in immunology · 2022Review
- Anti-inflammatory effect of baicalin in rats with adjuvant arthritis and its autophagy- related mechanism.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- Transcription factor EB promotes rheumatoid arthritis of Sprague-Dawley rats via regulating autophagy.3 Biotech · 2021Article
- Focus on the Multimodal Role of Autophagy in Rheumatoid Arthritis.Inflammation · 2021Review
- Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.Pharmaceutical biology · 2020Article
- Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management.Journal of cellular and molecular medicine · 2020Review
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.International journal of oncology · 2020Article
- Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy.Journal of immunology research · 2020Article
- Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression.Frontiers in physiology · 2020Article
- Baicalin attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.Journal of cell communication and signaling · 2019Article
- Metabolomics study of the therapeutic mechanism of a Chinese herbal formula on collagen-induced arthritis mice.RSC advances · 2019Article
- Tomorou attenuates progression of rheumatoid arthritis through alteration in ULK-1 independent autophagy pathway in collagen induced arthritis mice model.Cell death discovery · 2019Article
- Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.Arthritis research & therapy · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder of immunregulation. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, the potential mechanism of RA-FLS in regulating the immnue response is not clearly understood. In this study, we demonstrated that the expression of HIF-1α was significantly up-regulated in rheumatoid arthritis tissue which indicated that the hypoxia condition in the microenvironment. We also observed that RA-FLSs demonstrated the potential to up-regulate immune activation. Meanwhile, the level of autophagy increased in RA-FLSs compared with control group. Besides that, the expression of IL-6 was up-regulated not only in RA-FLSs but also in the fibroblasts that treated with hypoxia condition. Accordingly, we found that autophagy inhibitiors could effectively inhibit the immune activation function of RA-FLSs medicated by IL-6. Taken together, the results we demonstrated above indicated that the hypoxia microenvironment could effectively induce the incidence of autophagy and then lead to the immune activation function of RA-FLSs medicated by IL-6.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.