ReviewJournal of neurophysiology2017
Comparative biology of pain: What invertebrates can tell us about how nociception works.
Review in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Starvation transforms signal encoding ineLife · 2026Article
- Starvation transforms signal encoding inbioRxiv : the preprint server for biology · 2026Article
- Habituation and sensitization learning in adult solitary ascidians.Scientific reports · 2026Article
- The paraEuropean journal of pain (London, England) · 2026Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Neuroimmune Pain and Its Manipulation by Pathogens.Evolutionary applications · 2025Article
- Article
- Multiple mechanisms of action for an extremely painful venom.Current biology : CB · 2025Article
- Defending and refining the BirchAnimal welfare (South Mimms, England) · 2025Review
- The influence of sex on neuroimmune communication, pain, and physiology.Biology of sex differences · 2024Review
- Multiple mechanisms of action of an extremely painful venom.bioRxiv : the preprint server for biology · 2024Article
- Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior ineLife · 2024Article
- Neuroanatomy of the nociceptive system: From nociceptors to brain networks.International review of neurobiology · 2024Review
- Behavioral and pharmacological characterization of planarian nociception.Frontiers in molecular neuroscience · 2024Article
- Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila.Nature communications · 2023Article
- I Feel! Therefore, I Am from Pain to Consciousness in DOC Patients.International journal of molecular sciences · 2023Review
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- Article
- Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.Genetics · 2023Article
- Phylogenetic Analysis Provides Insight Into the Molecular Evolution of Nociception and Pain-Related Proteins.Evolutionary bioinformatics online · 2023Article
Corrections and comments
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Abstract
The inability to adequately treat chronic pain is a worldwide health care crisis. Pain has both an emotional and a sensory component, and this latter component, nociception, refers specifically to the detection of damaging or potentially damaging stimuli. Nociception represents a critical interaction between an animal and its environment and exhibits considerable evolutionary conservation across species. Using comparative approaches to understand the basic biology of nociception could promote the development of novel therapeutic strategies to treat pain, and studies of nociception in invertebrates can provide especially useful insights toward this goal. Both vertebrates and invertebrates exhibit segregated sensory pathways for nociceptive and nonnociceptive information, injury-induced sensitization to nociceptive and nonnociceptive stimuli, and even similar antinociceptive modulatory processes. In a number of invertebrate species, the central nervous system is understood in considerable detail, and it is often possible to record from and/or manipulate single identifiable neurons through either molecular genetic or physiological approaches. Invertebrates also provide an opportunity to study nociception in an ethologically relevant context that can provide novel insights into the nature of how injury-inducing stimuli produce persistent changes in behavior. Despite these advantages, invertebrates have been underutilized in nociception research. In this review, findings from invertebrate nociception studies are summarized, and proposals for how research using invertebrates can address questions about the fundamental mechanisms of nociception are presented.
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