Evidence map›Paper›PMID 28053225›Full record

ArticlePhysiological reports2017

The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.

Henriette L Christensen, Teodor G Păunescu, Vladimir Matchkov, Dagne Barbuskaite, Dennis Brown, Helle H Damkier, Jeppe Praetorius

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Consideration of Kinase Inhibitors for the Treatment of Hydrocephalus.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Choroid plexus epithelium and its role in neurological diseases.Frontiers in molecular neuroscience · 2022
    Review
  6. Article
  7. Genetic and pharmacological inactivation of apical NaAmerican journal of physiology. Cell physiology · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Henriette L ChristensenDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.
Teodor G PăunescuCenter for Systems Biology, Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Vladimir MatchkovDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark.
Dagne BarbuskaiteDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark.
Dennis BrownCenter for Systems Biology, Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Helle H DamkierDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark.
Jeppe PraetoriusDepartment of Biomedicine, Health, Aarhus University, Aarhus, Denmark jp@ana.au.dk.
Aarhus University · DKHarvard University · USUniversity of Copenhagen · DK

Funding

Regulation of proton pump trafficking in kidneyR37DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2008 to 2017
$4.0M
NIDDK NIH HHS R37 DK042956
6 · The paper itself

Abstract

The cerebrospinal fluid (CSF) pH influences brain interstitial pH and, therefore, brain function. We hypothesized that the choroid plexus epithelium (CPE) expresses the vacuolar H

Indexed as

8-Bromo Cyclic Adenosine MonophosphateAnimalsBrainCell MembraneCerebrospinal FluidChoroid PlexusCyclic AMPEnzyme InhibitorsFlow CytometryHydrogen-Ion ConcentrationIntracellular FluidMacrolidesMaleMiceMice, Inbred C57BLRNA, Messenger8-((4-chlorophenyl)thio)cyclic-3',5'-AMP8-Bromo Cyclic Adenosine Monophosphate8-chloro-cyclic adenosine monophosphateconcanamycin ACyclic AMPEnzyme InhibitorsMacrolidesRNA, MessengerSodiumThionucleotidesVacuolar Proton-Translocating ATPasesBCECF fluorometrycerebrospinal fluidfluorescence‐activated cell sortingpH regulation

Identifiers

PMID28053225
PMCPMC5256157
OpenAlexW2570849921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.