Evidence map›Paper›PMID 28053109›Full record

ArticleJournal of virology2017

Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.

Shanna L Ashley, Carla D Pretto, Matthew T Stier, Padma Kadiyala, Luiza Castro-Jorge, Tien-Huei Hsu, Robert Doherty, Kelly E Carnahan, Maria G Castro, Pedro R Lowenstein and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. The Causes and Long-Term Consequences of Viral Encephalitis.Frontiers in cellular neuroscience · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. MMPs and ADAMs in neurological infectious diseases and multiple sclerosis.Cellular and molecular life sciences : CMLS · 2019
    Review
  13. Article
  14. Article
  15. Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  16. Article
  17. Insights into the pathogenesis of herpes simplex encephalitis from mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shanna L AshleyDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Carla D PrettoDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Matthew T StierDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Padma KadiyalaDepartments of Neurosurgery and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Luiza Castro-JorgeDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Tien-Huei HsuDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Robert DohertyDepartments of Neurosurgery and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Kelly E CarnahanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Maria G CastroDepartments of Neurosurgery and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Pedro R LowensteinDepartments of Neurosurgery and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Katherine R SpindlerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA krspin@umich.edu.
University of Michigan–Ann Arbor · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Immune-suppressive Myeloid Cells in the Glioma Microenvironment: Signaling Mechanisms and Novel Therapeutic StrategiesR37NS094804 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2021
$2.9M
Mechanisms of blood-brain barrier disruption by an encephalitic virusR01AI091721 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2011 to 2015
$2.5M
MOLECULAR BIOLOGY &PATHOGENESIS OF ADENOVIRUSR01AI023762 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 1987 to 2007
$2.2M
Neuroimmunology of Malignant Brain Tumors: Innate MechanismsR01NS096756 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2016 to 2020
$2.1M
Engineering the Brain Immune System for Tumor TherapyR01NS057711 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2009 to 2013
$2.0M
Crosstalk between glioma cells & immune cells in the tumor microenvironment: TherR01NS074387 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2011 to 2015
$1.9M
Cloning a major gene for mouse adenovirus susceptibilityR01AI068645 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2006 to 2010
$1.9M
Mechanisms of glioma growth and invasion novel therapeutic strategiesR01NS082311 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2013 to 2017
$1.7M
HDL-Loaded Nanoparticles for Glioma TherapeuticsR21NS091555 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2016
$427k
Inhibiting glioma invasion using targeted nanoparticlesR21NS084275 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2013 to 2014
$420k
Molecular biology and pathogenesis of mouse adenovirusR56AI023762 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2010 to 2010
$387k
NCI NIH HHS P30 CA046592NIAID NIH HHS R01 AI023762NIAID NIH HHS R01 AI068645NIAID NIH HHS R01 AI091721NIAID NIH HHS R56 AI023762NINDS NIH HHS R01 NS057711NINDS NIH HHS R01 NS074387NINDS NIH HHS R01 NS082311NINDS NIH HHS R01 NS096756NINDS NIH HHS R21 NS084275NINDS NIH HHS R21 NS091555NINDS NIH HHS R37 NS094804
6 · The paper itself

Abstract

Mouse adenovirus type 1 (MAV-1) infection causes encephalitis in susceptible strains of mice and alters the permeability of infected brains to small molecules, which indicates disruption of the blood-brain barrier (BBB). Under pathological conditions, matrix metalloproteinases (MMPs) can disrupt the BBB through their proteolytic activity on basement membrane and tight junction proteins. We examined whether MAV-1 infection alters MMP activity

Indexed as

Adenoviridae InfectionsAnimalsAstrocytesBrainCells, CulturedDisease Models, AnimalEncephalitis, ViralEndothelial CellsMastadenovirusMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMicrogliaMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, mouseMmp9 protein, mouseastrocytesencephalitisendothelialendothelial cellsmatrix metalloproteinasemicroglia

Identifiers

PMID28053109
PMCPMC5331797
OpenAlexW2570843452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.