Evidence map›Paper›PMID 28053103›Full record

ArticleJournal of virology2017

Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication

Evan S Jacobs, Sheila M Keating, Mohamed Abdel-Mohsen, Stuart L Gibb, John W Heitman, Heather C Inglis, Jeffrey N Martin, Jinbing Zhang, Zhanna Kaidarova, Xutao Deng and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The multifaceted role of XCL1 in health and disease.Protein science : a publication of the Protein Society · 2025
    Review
  9. Natural Resistance to HIV Infection: Role of Immune Activation.Immunity, inflammation and disease · 2025
    Review
  10. HIV controllers: hope for a functional cure.Frontiers in immunology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. T-Follicular-Like CD8Frontiers in immunology · 2022
    Article
  15. Article
  16. Reversal of the CD8Frontiers in immunology · 2021
    Article
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 1 country.

Evan S JacobsBlood Systems Research Institute, San Francisco, California, USA.
Sheila M KeatingBlood Systems Research Institute, San Francisco, California, USA skeating@bloodsystems.org pnorris@bloodsystems.org.
Mohamed Abdel-MohsenBlood Systems Research Institute, San Francisco, California, USA.
Stuart L GibbBlood Systems Research Institute, San Francisco, California, USA.
John W HeitmanBlood Systems Research Institute, San Francisco, California, USA.
Heather C InglisBlood Systems Research Institute, San Francisco, California, USA.
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Jinbing ZhangJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Zhanna KaidarovaBlood Systems Research Institute, San Francisco, California, USA.
Xutao DengBlood Systems Research Institute, San Francisco, California, USA.
Shiquan WuBlood Systems Research Institute, San Francisco, California, USA.
Kathryn AnastosAlbert Einstein College of Medicine, Bronx, New York, USA.
Howard CrystalSUNY Downstate Medical Center, Brooklyn, New York, USA.
Maria C VillacresKeck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Mary YoungGeorgetown University Medical Center, Washington, DC, USA.
Ruth M GreenblattDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Alan L LandayRush University Medical Center, Chicago, Illinois, USA.
Stephen J GangeJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Steven G DeeksDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Elizabeth T GolubJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Satish K PillaiBlood Systems Research Institute, San Francisco, California, USA.
Philip J NorrisBlood Systems Research Institute, San Francisco, California, USA skeating@bloodsystems.org pnorris@bloodsystems.org.ORCID http://orcid.org/0000-0003-0526-2088
Blood Systems Research Institute · USUniversity of California, San Francisco · USJohns Hopkins University · USAlbert Einstein College of Medicine · USGeorgetown University · USRush University Medical Center · USSUNY Downstate Health Sciences University · USUniversity of Southern California · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01GM117901 · NIGMS · VITALANT · PI PILLAI, SATISH KUMAR · 2015 to 2018
$1.5M
Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01AI150449 · NIAID · VITALANT · PI PILLAI, SATISH KUMAR · 2019 to 2019
$305k
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI150449NIGMS NIH HHS R01 GM117901
6 · The paper itself

Abstract

A subset of HIV-infected individuals termed elite controllers (ECs) maintain CD4

Indexed as

AdultAntigens, DifferentiationCD4-Positive T-LymphocytesCytokinesFemaleGene Expression RegulationHIVHIV InfectionsHIV Long-Term SurvivorsHumansMembrane ProteinsMiddle AgedPlasmaReceptors, HIVVirus ReplicationAntigens, DifferentiationCytokinesIFITM2 protein, humanleu-13 antigenMembrane ProteinsReceptors, HIVchemokine receptorscytokineselite controlHIVrestriction factor

Identifiers

PMID28053103
PMCPMC5331794
OpenAlexW2568629935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.