Evidence map›Paper›PMID 28053034›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.

Christopher H Ferguson, Haiqing Zhao

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017
    Review
  6. Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher H FergusonDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218.ORCID 0000-0002-3225-4932
Haiqing ZhaoDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, 21218 hzhao@jhu.edu.ORCID 0000-0003-4275-9843
Johns Hopkins University · US

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Regulation of Olfactory Signal TransductionR01DC007395 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ZHAO, HAIQING · 2008 to 2016
$3.5M
Acquisition of Sony Biotechnology iCyt Synergy SY3200 BSC Cell SorterS10OD016230 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2014 to 2014
$520k
NIDCD NIH HHS R01 DC007395NIGMS NIH HHS T32 GM007231NIH HHS S10 OD016230
6 · The paper itself

Abstract

In vertebrate olfactory sensory neurons (OSNs), Ca SIGNIFICANCE STATEMENT: Sensory receptor cells maintain high sensitivity at rest. Although the mechanisms responsible for setting the resting sensitivity of sensory receptor cells are not well understood, it has generally been assumed that the sensitivity is set primarily by how effectively the components in the activation cascade of sensory transduction can be stimulated. Our findings in mouse olfactory sensory neurons suggest that mechanisms that are primarily responsible for terminating the olfactory response are also critical for proper resting sensitivity.

Indexed as

AnimalsAntiportersCalciumCalcium-Calmodulin-Dependent Protein KinasesCyclic Nucleotide-Gated Cation ChannelsFemaleMaleMiceMice, KnockoutMutationNerve Tissue ProteinsOlfactory MucosaOlfactory Receptor NeuronsSignal TransductionSmellAntiportersCalciumCalcium-Calmodulin-Dependent Protein KinasesCngb1 protein, mouseCyclic Nucleotide-Gated Cation ChannelsNerve Tissue ProteinsSlc24a4 protein, mousecalcium regulationCNG channelolfactory adaptationolfactory transductionsensitivitysodium-calcium exchanger

Identifiers

PMID28053034
PMCPMC5214624
OpenAlexW2553330495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.