ArticleSchizophrenia bulletin2017
Biological Mechanisms Whereby Social Exclusion May Contribute to the Etiology of Psychosis: A Narrative Review.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Migration and psychosis: a meta-analysis of incidence studies.Psychological medicine · 2020Pooled it
- Oxytocin increases eye gaze in schizophrenia.Schizophrenia research · 2019Trial
- Social exclusion as a determinant of excess mortality in people with schizophrenia-spectrum and bipolar disorders: retrospective cohort study in 0.5 million people.Psychological medicine · 2025Article
- Viewing social isolation as a complex dynamical system: A theoretical and computational framework.NPP - digital psychiatry and neuroscience · 2025Article
- Online racism and psychotic experiences among Black American and Asian/Native Hawaiian/Pacific Islander American emerging adults in the United States.Schizophrenia research · 2025Article
- Self-other boundary under social threat in schizophrenia.Schizophrenia research · 2024Article
- Altered representation of peripersonal and interpersonal space in psychopathology.Clinical psychology review · 2024Review
- Stress, Environment and Early Psychosis.Current neuropharmacology · 2024Review
- Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders: III. Biology.Schizophrenia bulletin · 2023Article
- Health outcomes in young adulthood among former child refugees in Denmark, Norway and Sweden: A cross-country comparative study.Scandinavian journal of public health · 2023Article
- Psychotic experiences, sexual minority status, and suicidal behavior among young adult college students in the United States.Social psychiatry and psychiatric epidemiology · 2022Article
- The incidence of psychotic disorders among migrants and minority ethnic groups in Europe: findings from the multinational EU-GEI study.Psychological medicine · 2022Article
- Biopsychosocial exposure to the COVID-19 pandemic and the relative risk of schizophrenia: Interrupted time-series analysis of a nationally representative sample.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Cerebral [Diagnostics (Basel, Switzerland) · 2021Article
- Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study.Psychological medicine · 2021Article
- The representation of mental state information in schizophrenia and first-degree relatives: a multivariate pattern analysis of fMRI data.Social cognitive and affective neuroscience · 2021Article
- Striatal dopamine synthesis capacity in autism spectrum disorder and its relation with social defeat: an [Translational psychiatry · 2021Article
- Retinal Microvasculature in Schizophrenia.Eye and brain · 2021Article
- Deterioration of mental health despite successful control of the COVID-19 pandemic in South Korea.Psychiatry research · 2021Article
- Trauma and Social Pathways to Psychosis, and Where the Two Paths Meet.Frontiers in psychiatry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this review is to examine whether a contribution of social exclusion to the pathogenesis of psychosis is compatible with the dopamine hypothesis and/or the neurodevelopmental hypothesis. Humans experience social exclusion as defeating. An animal model for defeat is the resident-intruder paradigm. The defeated animal shows evidence of an increased sensitivity to amphetamine, increased dopamine release in the nucleus accumbens and prefrontal cortex, and increased firing of dopaminergic neurons in the ventral tegmental area. As for humans, one study showed that amphetamine-induced striatal dopamine release was significantly greater among nonpsychotic young adults with severe hearing impairment than among normal hearing controls. Two other studies reported an association between childhood trauma and increased dopamine function in striatal subregions. Several studies have suggested that the perigenual anterior cingulate cortex (pgACC) may play a role in the processing of social stress. Importantly, the pgACC regulates the activity of the ventral striatum through bidirectional interconnections. We are not aware of studies in humans that examined whether (proxies for) social exclusion contributes to the structural brain changes present at psychosis onset. Animal studies, however, reported that long-term isolation may lead to reductions in volume of the total brain, hippocampus, or medial prefrontal cortex. Other animal studies reported that social defeat can reduce neurogenesis. In conclusion, the answer to the question as to whether there are plausible mechanisms whereby social exclusion can contribute to the pathogenesis of psychosis is cautiously affirmative.
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