Evidence map›Paper›PMID 28052994›Full record

ArticleInfection and immunity2017

Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection.

Allison K Ehrlich, Olga L Fernández, Daniel Rodriguez-Pinto, Tiago M Castilho, Maria J Corral Caridad, Karen Goldsmith-Pestana, Nancy Gore Saravia, Diane McMahon-Pratt

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Harnessing the Induction of CD8Frontiers in immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Allison K EhrlichYale University School of Public Health, New Haven, Connecticut, USA allisonk.ehrlich@gmail.com.
Olga L FernándezCentro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
Daniel Rodriguez-PintoCentro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
Tiago M CastilhoYale University School of Public Health, New Haven, Connecticut, USA.
Maria J Corral CaridadDepartment of Animal Health, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Karen Goldsmith-PestanaYale University School of Public Health, New Haven, Connecticut, USA.
Nancy Gore SaraviaCentro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
Diane McMahon-PrattYale University School of Public Health, New Haven, Connecticut, USA.
Yale University · USCentro Internacional de Entrenamiento e Investigaciones Medicas · COUniversidad Complutense de Madrid · ESUniversidad de Las Américas · EC

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Vector/Host-Parasite Interface of Leishmaniasis in ColombiaD43TW006589 · FIC · YALE UNIVERSITY · PI GORE SARAVIA, NANCY, TSCHUDI, CHRISTIAN · 2003 to 2024
$4.3M
Training in Parasitology and Vector BiologyT32AI007404 · NIAID · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 1991 to 2017
$3.8M
Improved Treatment of American Cutaneous Leishmaniasis by ImmunomodulationR01AI093775 · NIAID · YALE UNIVERSITY · PI GORE SARAVIA, NANCY, MCMAHON PRATT, DIANE · 2011 to 2014
$2.6M
FIC NIH HHS D43 TW006589NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI093775NIAID NIH HHS T32 AI007404
6 · The paper itself

Abstract

Infection by

Indexed as

AdultAnimalsChronic DiseaseCytokinesFemaleHumansImmunomodulationLeishmania guyanensisLeishmaniasis, MucocutaneousLigandsMaleMiceMiddle AgedOligodeoxyribonucleotidesParasite LoadT-Lymphocyte SubsetsCytokinesLigandsOligodeoxyribonucleotidesToll-Like Receptor 9CpGimmunomodulationinflammationLeishmaniaTreg

Identifiers

PMID28052994
PMCPMC5328479
OpenAlexW2568280920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.