Evidence map›Paper›PMID 28052988›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Potassium Sensing by Renal Distal Tubules Requires Kir4.1.

Catherina A Cuevas, Xiao-Tong Su, Ming-Xiao Wang, Andrew S Terker, Dao-Hong Lin, James A McCormick, Chao-Ling Yang, David H Ellison, Wen-Hui Wang

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 160 citations in OpenAlex.

  1. Review
  2. Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney KAmerican journal of physiology. Renal physiology · 2026
    Article
  3. Article
  4. Potassium and the kidney.Nature reviews. Nephrology · 2026
    Review
  5. Review
  6. The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026
    Review
  7. Article
  8. KiScience · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Role of KThe American journal of pathology · 2025
    Article
  14. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  15. mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  16. Role of calcineurin in regulating renal potassium (KActa physiologica (Oxford, England) · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Catherina A CuevasDivision of Nephrology and Hypertension, Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon.
Xiao-Tong SuDepartment of Pharmacology, New York Medical College, Valhalla, New York; and.
Ming-Xiao WangDepartment of Pharmacology, New York Medical College, Valhalla, New York; and.
Andrew S TerkerDivision of Nephrology and Hypertension, Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon.
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla, New York; and.
James A McCormickDivision of Nephrology and Hypertension, Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon.
Chao-Ling YangDivision of Nephrology and Hypertension, Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon.
David H EllisonDivision of Nephrology and Hypertension, Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon; Ellisond@ohsu.edu Wenhui_wang@nymc.edu.
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla, New York; and Ellisond@ohsu.edu Wenhui_wang@nymc.edu.
New York Medical College · USOregon Health & Science University · USVA Portland Health Care System · US

Funding

WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
Renal Effects of AldosteroneI01BX002228 · VA · PORTLAND VA MEDICAL CENTER · PI ELLISON, DAVID H · 2014 to 2021
–
BLRD VA I01 BX002228NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK098141NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

The mammalian distal convoluted tubule (DCT) makes an important contribution to potassium homeostasis by modulating NaCl transport. The thiazide-sensitive Na

Indexed as

PotassiumAnimalsKcnj10 ChannelKidney Tubules, DistalMicePotassium Channels, Inwardly RectifyingKcnj10 ChannelPotassiumPotassium Channels, Inwardly Rectifyingdiureticspotassium channelsslc12a3spakthiazidewnk4

Identifiers

PMID28052988
PMCPMC5461801
OpenAlexW2570063070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.