ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Effects of renal denervation on the course of cardiorenal syndrome: insight from studies with fawn-hooded hypertensive rats.Physiological research · 2024Article
- Renal Denervation in Heart Failure Treatment: Data for a Self-Fulfilling Prophecy.Journal of clinical medicine · 2024Review
- Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Pirfenidone increases transverse tubule length in the infarcted rat myocardium.Interface focus · 2023Article
- Human Pulmonary Vein Myocardial Sleeve Autonomic Neural Density and Cardiovascular Mortality.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Renal Sympathetic Denervation Improves Outcomes in a Canine Myocardial Infarction Model.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Modulation of renal sympathetic innervation: recent insights beyond blood pressure control.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Reconsidering Renal Sympathetic Denervation for Heart Failure.JACC. Basic to translational science · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery and progressed into heart failure for 4 wk before receiving bilateral RDx or sham RDx. After additional 3 wk, left ventricular (LV) function was assessed, and ventricular sympathetic nerve fiber density was determined via histology. Post-MI heart failure rats displayed significant reductions in ventricular sympathetic innervation and tissue norepinephrine content (nerve fiber density in the LV of MI+sham RDx hearts was 0.31 ± 0.05% vs. 1.00 ± 0.10% in sham MI+sham RDx group,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.