Evidence map›Paper›PMID 28052852›Full record

ArticleAntimicrobial agents and chemotherapy2017

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model.

Justin R Lenhard, Nicholas M Smith, Zackery P Bulman, Xun Tao, Visanu Thamlikitkul, Beom S Shin, Roger L Nation, Jian Li, Jürgen B Bulitta, Brian T Tsuji

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline for antimicrobial treatment of multidrug-resistant Gram-negative infections: practice recommendations of the Brazilian Society of Infectious Diseases.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  4. Review
  5. Sulbactam-Durlobactam for Carbapenem-ResistantPathogens (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Emergence of carbapenem-resistantAntimicrobial agents and chemotherapy · 2025
    Article
  11. Microbiology spectrum · 2025
    Article
  12. Article
  13. High Prevalence of Virulence andPathogens (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  19. Evaluation of the in vitro activity of ampicillin-sulbactam and cefoperazone-sulbactam against A. Baumannii by the broth disk elution test.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  20. Optimizing Treatment for Carbapenem-ResistantInfection & chemotherapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Justin R LenhardLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA.
Nicholas M SmithLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA.
Zackery P BulmanLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA.
Xun TaoCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Visanu ThamlikitkulDivision of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Beom S ShinCatholic University of Daegu, Hayang, South Korea.
Roger L NationDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Jian LiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Jürgen B BulittaCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Brian T TsujiLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA btsuji@buffalo.edu.
University at Buffalo, State University of New York · USMonash University · AUUniversity of Florida · USCatholic University of Daegu · KRSiriraj Hospital · TH

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Novel PK/PD Strategies for Polymyxin Combinations against Gram-negative SuperbugsR01AI111990 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JIAN, TSUJI, BRIAN · 2014 to 2018
$4.4M
NCATS NIH HHS UL1 TR001412NIAID NIH HHS R01 AI111990
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, StatisticalAcinetobacter baumanniiAcinetobacter InfectionsAmpicillinAnti-Bacterial AgentsArea Under CurveBiological AvailabilityBody Mass IndexDrug Administration ScheduleDrug CombinationsDrug Dosage CalculationsDrug Resistance, Multiple, BacterialDrug SynergismHumansMeropenemMicrobial Sensitivity TestsAmpicillinAnti-Bacterial AgentsDrug CombinationsMeropenemPolymyxin BSulbactamsultamicillinThienamycinsAcinetobacterantibiotic resistanceantimicrobial combinationsmeropenempolymyxinssulbactamsynergism

Identifiers

PMID28052852
PMCPMC5328540
OpenAlexW2568698844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.