Evidence map›Paper›PMID 28052822›Full record

ReviewAdvances in cancer research2017

Applying a Conceptual Framework to Maximize the Participation of Diverse Populations in Cancer Clinical Trials.

A Napoles, E Cook, T Ginossar, K D Knight, M E Ford

Abstract readReview
In one paragraph

Review in Advances in cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  13. Review
  14. Cancer Epidemiology in Hispanic Populations: What Have We Learned and Where Do We Need to Make Progress?Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A NapolesUniversity of California, San Francisco, CA, United States.
E CookUniversity of Texas MD Anderson Cancer Center, Houston, TX, United States.
T GinossarUniversity of New Mexico, Albuquerque, NM, United States.
K D KnightMedical University of South Carolina, Charleston, SC, United States.
M E FordHollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States. Electronic address: fordmar@musc.edu.

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nynikka Palmer · 1997 to 2026
$19.5M
NM MINORITY-BASED COMMUNITY CLINICAL ONC. PROGRAMU10CA086780 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROYCE, MELANIE E · 2000 to 2014
$8.8M
South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARROLL, STEVEN L. · 2017 to 2023
$6.7M
Training ProgramU54CA153511 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RAMIREZ, AMELIE G · 2010 to 2015
$6.2M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI WARSHAMANA-GREENE, GNANA SAKUNTALA · 2017 to 2023
$6.1M
Improving Resection Rates among African Americans with NSCLCR01MD005892 · NIMHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ESNAOLA, NESTOR F., FORD, MARVELLA ELIZABETH · 2012 to 2016
$1.8M
SC Cancer Disparities Research Center (2 of 2)P20CA157071 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FORD, MARVELLA ELIZABETH, SALLEY, JUDITH · 2011 to 2014
$835k
NCI NIH HHS P20 CA157071NCI NIH HHS P30 CA138313NCI NIH HHS U10 CA086780NCI NIH HHS U54 CA153511NCI NIH HHS U54 CA210962NCI NIH HHS U54 CA210963NIA NIH HHS P30 AG015272NIMHD NIH HHS R01 MD005892
6 · The paper itself

Abstract

The underrepresentation of ethnically diverse populations in cancer clinical trials results in the inequitable distribution of the risks and benefits of this research. Using a case study approach, we apply a conceptual framework of factors associated with the participation of diverse population groups in cancer clinical trials developed by Dr. Jean Ford and colleagues to increase understanding of the specific strategies, and barriers and promoters addressed by these strategies, that resulted in marked success in accrual of racially and ethnically diverse populations in cancer clinical research. Results indicate that the studies presented were able to successfully engage minority participants due to the creation and implementation of multilevel, multifaceted strategies that included: culturally and linguistically appropriate outreach, education, and research studies that were accessible in local communities; infrastructure to support engagement of key stakeholders, clinicians, and organizations serving minority communities; testimonials by ethnically diverse cancer survivors; availability of medical interpretation services; and providing infrastructure that facilitated the engagement in clinical research of clinicians who care for minority patient populations. These strategic efforts were effective in addressing limited awareness of trials, lack of opportunities to participate, and acceptance of engagement in cancer clinical trials. Careful attention to the context and population characteristics in which cancer clinical trials are conducted will be necessary to address disparities in research participation and cancer outcomes. These studies illustrate that progress on minority accrual into clinical research requires intentional efforts to overcome barriers at all three stages of the accrual process: awareness, opportunity, and acceptance of participation.

Indexed as

Health Status DisparitiesBiomedical ResearchClinical Trials as TopicEthnicityHealth Knowledge, Attitudes, PracticeHumansMinority GroupsNeoplasmsPatient ParticipationResearch DesignCancer clinical trialsConceptual frameworkDiverse populationsRecruitment

Identifiers

PMID28052822
PMCPMC5542779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.