Evidence map›Paper›PMID 28052821›Full record

ReviewAdvances in cancer research2017

MicroRNAs and Their Impact on Breast Cancer, the Tumor Microenvironment, and Disparities.

A Evans-Knowell, A C LaRue, V J Findlay

Open access · greenAbstract readReview
In one paragraph

Review in Advances in cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Revision Mastopexy in Aesthetic Breast Surgery.Aesthetic plastic surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

A Evans-KnowellSouth Carolina State University, Orangeburg, SC, United States.
A C LaRueResearch Services, Ralph H. Johnson VAMC, Medical University of South Carolina, Charleston, SC, United States; Medical University of South Carolina, Charleston, SC, United States; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States.
V J FindlayMedical University of South Carolina, Charleston, SC, United States; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States. Electronic address: findlay@musc.edu.
Medical University of South Carolina · USMUSC Hollings Cancer Center · USSouth Carolina State University · US

Funding

South Carolina Cancer Disparities Research Center (SC CADRE)U54CA210962 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FORD, MARVELLA ELIZABETH, SALLEY, JUDITH · 2017 to 2023
$6.7M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI WARSHAMANA-GREENE, GNANA SAKUNTALA · 2017 to 2023
$6.1M
Hematopoietic Stem Cell-Derived Carcinoma Associated Fibroblasts in TumorR01CA148772 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LARUE, AMANDA C. · 2011 to 2015
$1.3M
SC Cancer Disparities Research Center (2 of 2)P20CA157071 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FORD, MARVELLA ELIZABETH, SALLEY, JUDITH · 2011 to 2014
$835k
SC Cancer Disparties Research Center (1 of 2)P20CA157066 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI SALLEY, JUDITH · 2011 to 2014
$403k
NCI NIH HHS P20 CA157066NCI NIH HHS P20 CA157071NCI NIH HHS R01 CA148772NCI NIH HHS U54 CA210962NCI NIH HHS U54 CA210963
6 · The paper itself

Abstract

Breast cancer is a worldwide health issue as it represents the leading cause of cancer in women and the second-leading cause of cancer-related mortality in women, with an increasing incidence. Nothing speaks more clearly to the shocking breast cancer health disparities than the fact that African American (AA) women are as likely to get breast cancer as Caucasian American (CA) women, yet have a higher breast cancer death rate. It is becoming increasingly apparent that racial disparity in cancer exists due to molecular differences in tumor biology as well as, or in addition to, socioeconomic and standard of care issues (Albain, Unger, Crowley, Coltman, & Hershman, 2009). A greater understanding of the risk factors and biological links associated with breast cancer, will significantly impact AA communities due to the higher deaths associated with this disease in this population. microRNAs are small noncoding RNA molecules that were recently discovered as major players in the regulation of many diseases including cancer. Although, there are many studies that have investigated the role of miRNAs in breast cancer, few have investigated their role if any in breast cancer disparities. This review serves to summarize the current published literature that is involved in the study of microRNAs and their impact on breast cancer disparities.

Indexed as

Health Status DisparitiesTumor MicroenvironmentBreast NeoplasmsEthnicityFemaleHumansMicroRNAsRisk FactorsMicroRNAsBreast cancerCancer-associated fibroblastDisparitiesmicroRNASingle nucleotide polymorphismsTumor-associated macrophagesTumor microenvironment

Identifiers

PMID28052821
PMCPMC8311570
OpenAlexW2526916728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.