Evidence map›Paper›PMID 28052328›Full record

ArticleInternational journal of cancer2017

Type-dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18.

Long Fu Xi, Mark Schiffman, Yang Ke, James P Hughes, Denise A Galloway, Zhonghu He, Ayaka Hulbert, Rachel L Winer, Laura A Koutsky, Nancy B Kiviat

Abstract read
In one paragraph

Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Role of HPV Genotype, Multiple Infections, and Viral Load on the Risk of High-Grade Cervical Neoplasia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
  15. Article
  16. Changes in DNA Level of Oncogenic Human Papillomaviruses Other Than Types 16 and 18 in Relation to Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Long Fu XiDepartment of Pathology, School of Medicine, University of Washington, Seattle, WA.
Mark SchiffmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Yang KeKey Laboratory of Carcinogenesis and Translational Research, Peking University School of Oncology, Beijing, People's Republic of China.
James P HughesDepartment of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA.
Denise A GallowayDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA.
Zhonghu HeKey Laboratory of Carcinogenesis and Translational Research, Peking University School of Oncology, Beijing, People's Republic of China.
Ayaka HulbertDepartment of Pathology, School of Medicine, University of Washington, Seattle, WA.
Rachel L WinerDepartment of Epidemiology, University of Washington, Seattle, WA.
Laura A KoutskyDepartment of Epidemiology, University of Washington, Seattle, WA.
Nancy B KiviatDepartment of Pathology, School of Medicine, University of Washington, Seattle, WA.

Funding

INTERACTIONS OF HPV ONCOGENES WITH THE P53 PATHWAYR01CA064795 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GALLOWAY, DENISE A. · 1995 to 2017
$8.6M
Human Papillomavirus and Polyomavirus Associated Malignancies.R35CA209979 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GALLOWAY, DENISE A. · 2017 to 2023
$6.5M
Intratypic variation of oncogenic HPV types as a risk factor for cervical neoplasR01CA133569 · NCI · UNIVERSITY OF WASHINGTON · PI XI, LONG FU · 2009 to 2012
$1.7M
NCI NIH HHS R01 CA064795NCI NIH HHS R01 CA133569NCI NIH HHS R35 CA209979
6 · The paper itself

Abstract

Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) triage study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals. Viral load measurements were performed on the first type-specific HPV-positive specimens. The association of cervical intraepithelial neoplasia grades 2-3 (CIN2/3) with type-specific HPV DNA load was assessed with discrete-time Cox regression. Overall, the increase in the cumulative risk of CIN2/3 per 1 unit increase in log

Indexed as

DNA, ViralEarly Detection of CancerFemaleGenotypeHuman papillomavirus 16Human papillomavirus 18Human papillomavirus 31HumansPapillomaviridaePapillomavirus InfectionsUterine Cervical DysplasiaVaginal SmearsViral LoadDNA, Viralcervical intraepithelial neoplasiahuman papillomavirusrisk associationviral load

Identifiers

PMID28052328
PMCPMC6014600

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.