ArticleCell reports2017
Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evolutionary conservation of midline axon guidance activity between Drosophila and Tribolium Frazzled.Developmental biology · 2026Article
- Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance.Science advances · 2025Article
- Article
- Semaphorin 3A on Osteoporosis: An Overreview of the Literature.Calcified tissue international · 2025Review
- Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance.Development (Cambridge, England) · 2023Article
- Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw.European journal of medical research · 2023Article
- Semaphorin 1a-mediated dendritic wiring of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular mechanisms regulating axon responsiveness at the midline.Developmental biology · 2020Article
- The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance.Neural development · 2020Article
- Identification ofMolecules and cells · 2020Article
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.Nature cell biology · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways.Neural plasticity · 2019Review
- Axon formation, extension, and navigation: only a neuroscience phenomenon?Current opinion in neurobiology · 2018Review
- Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.PLoS genetics · 2018Article
- Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The laminar organization of theeLife · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Commissural axons must cross the midline to form functional midline circuits. In the invertebrate nerve cord and vertebrate spinal cord, midline crossing is mediated in part by Netrin-dependent chemoattraction. Loss of crossing, however, is incomplete in mutants for Netrin or its receptor Frazzled/DCC, suggesting the existence of additional pathways. We identified the transmembrane Semaphorin, Sema-1a, as an important regulator of midline crossing in the Drosophila CNS. We show that in response to the secreted Semaphorins Sema-2a and Sema-2b, Sema-1a functions as a receptor to promote crossing independently of Netrin. In contrast to other examples of reverse signaling where Sema1a triggers repulsion through activation of Rho in response to Plexin binding, in commissural neurons Sema-1a acts independently of Plexins to inhibit Rho to promote attraction to the midline. These findings suggest that Sema-1a reverse signaling can elicit distinct axonal responses depending on differential engagement of distinct ligands and signaling effectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.