ArticleCell reports2017
Brain State Dependence of Hippocampal Subthreshold Activity in Awake Mice.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Noncanonical circuits, states, and computations of the hippocampus.Science (New York, N.Y.) · 2025Review
- Brain State-Dependent Neocortico-Hippocampal Network Dynamics Are Modulated by Postnatal Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Reward Expectation Reduces Representational Drift in the Hippocampus.bioRxiv : the preprint server for biology · 2023Article
- Article
- Article
- Remapping in a recurrent neural network model of navigation and context inference.bioRxiv : the preprint server for biology · 2023Article
- Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral.Frontiers in cellular neuroscience · 2023Article
- Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types.Science (New York, N.Y.) · 2022Article
- Article
- Review
- Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics.Science (New York, N.Y.) · 2022Article
- Fear conditioning potentiates the hippocampal CA1 commissural pathway in vivo and increases awake phase sleep.Hippocampus · 2021Article
- Dynamic and reversible remapping of network representations in an unchanging environment.Neuron · 2021Article
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Dentate Gyrus Sharp Waves, a Local Field Potential Correlate of Learning in the Dentate Gyrus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Single-Cell Membrane Potential Fluctuations Evince Network Scale-Freeness and Quasicriticality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Internal representation of hippocampal neuronal population spans a time-distance continuum.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Monitoring the membrane potential of individual neurons has uncovered how single-cell properties contribute to network processing across different brain states in neocortex. In contrast, the subthreshold modulation of hippocampal neurons by brain state has not been systematically characterized. To address this, we combined whole-cell recordings from dentate granule cells and CA1 pyramidal neurons with multisite extracellular recordings and behavioral measurements in awake mice. We show that the average membrane potential, amplitude of subthreshold fluctuations, and distance to spike threshold are all modulated by brain state. Furthermore, even within individual states, rapid variations in arousal are reflected in membrane potential fluctuations. These factors produce depolarizing ramps in the membrane potential of hippocampal neurons that precede ripples and mirror transitions to a network regime conducive for ripple generation. These results suggest that there are coordinated shifts in the subthreshold dynamics of individual neurons that underlie the transitions between distinct modes of hippocampal processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.