ArticleVirulence2017
Antimicrobial capacity of the freshwater planarians against S. aureus is under the control of Timeless.
Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Why study sleep in flatworms?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Persistence of Nocturnality in Decapitated and Bisected Flatworms.Journal of biological rhythms · 2023Article
- Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea.Scientific reports · 2021Article
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- Planarians (Platyhelminthes)-An Emerging Model Organism for Investigating Innate Immune Mechanisms.Frontiers in cellular and infection microbiology · 2021Review
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- Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity acrossGenome research · 2019Article
- The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections.Developmental and comparative immunology · 2019Article
- The Bacterial Metabolite Indole Inhibits Regeneration of the Planarian Flatworm Dugesia japonica.iScience · 2018Article
- Temperature affects the biology of Schmidtea mediterranea.Scientific reports · 2018Article
- Planarian finds time(less) to fight infection.Virulence · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.