Evidence map›Paper›PMID 28051179›Full record

ArticleScientific reports2017

The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation.

Xiao Xi, Lu Lu, Chun-Chun Zhuge, Xuebing Chen, Yuanfen Zhai, Jingjing Cheng, Haian Mao, Chang-Ching Yang, Bertrand Chin-Ming Tan, Yi-Nan Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Xiao XiResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Lu LuResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Chun-Chun ZhugeResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Xuebing ChenResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Yuanfen ZhaiResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Jingjing ChengResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Haian MaoResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Chang-Ching YangDepartment of Biomedical Sciences and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan.
Bertrand Chin-Ming TanDepartment of Biomedical Sciences and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan.
Yi-Nan LeeInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Cheng-Ting ChienInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Margaret S HoResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.
Tongji University · CNShanghai East Hospital · CNChang Gung University · TWInstitute of Molecular Biology, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiated neurons and glia are acquired from immature precursors via transcriptional controls exerted by factors such as proteins in the family of Glial Cells Missing (Gcm). Mammalian Gcm proteins mediate neural stem cell induction, placenta and parathyroid development, whereas Drosophila Gcm proteins act as a key switch to determine neuronal and glial cell fates and regulate hemocyte development. The present study reports a hypoparathyroidism-associated mutation R59L that alters Drosophila Gcm (Gcm) protein stability, rendering it unstable, and hyperubiquitinated via the ubiquitin-proteasome system (UPS). Gcm

Indexed as

AnimalsDNADNA-Binding ProteinsDrosophilaDrosophila ProteinsHumansHypoparathyroidismLeupeptinsNeurogliaNuclear ProteinsPhosphorylationPolymorphism, Single NucleotideProteasome Endopeptidase ComplexProtein BindingProtein Kinase CProtein Stabilitybenzyloxycarbonylleucyl-leucyl-leucine aldehydeDNADNA-Binding ProteinsDrosophila ProteinsGCM2 protein, humanGCM protein, DrosophilaLeupeptinsNuclear ProteinsProteasome Endopeptidase ComplexProtein Kinase CTranscription FactorsUbiquitin

Identifiers

PMID28051179
PMCPMC5209662
OpenAlexW2568682726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.