ArticleScientific reports2017
Metal transport protein 8 in Camellia sinensis confers superior manganese tolerance when expressed in yeast and Arabidopsis thaliana.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Aluminium Alleviates Manganese Toxicity by Regulating the CsNRAMP5 Transporter in Tea Plant (Camellia sinensis).Plant, cell & environment · 2026Article
- Genome-wide identification and analysis of the Delay Of Germination 1 (DOG1) gene family in Brassica napus and its potential role in Manganese (Mn) stress response.BMC plant biology · 2026Article
- Systematic mining and characterization of metal transporter families regulating zinc homeostasis provide insights into metal homeostasis inFrontiers in plant science · 2026Article
- Transcriptome-based analysis reveals key molecular mechanisms and functional characterization of MaCAX3 gene involved in manganese stress responses in mulberry plants.BMC plant biology · 2025Article
- Review
- Deciphering the functional roles of transporter proteins in subcellular metal transportation of plants.Planta · 2023Review
- Dissecting the relative contribution of ECA3 and group 8/9 cation diffusion facilitators to manganese homeostasis inPlant direct · 2023Article
- Proteomic and Genomic Studies of Micronutrient Deficiency and Toxicity in Plants.Plants (Basel, Switzerland) · 2022Review
- MTP8 fromInternational journal of molecular sciences · 2022Article
- Genome-Wide Analysis of theFrontiers in plant science · 2022Article
- Characterisation of manganese toxicity tolerance inPlant diversity · 2021Article
- Characterization of Metal Tolerance Proteins and Functional Analysis of GmMTP8.1 Involved in Manganese Tolerance in Soybean.Frontiers in plant science · 2021Article
- Physiological and transcriptomic analyses reveal the roles of secondary metabolism in the adaptive responses of Stylosanthes to manganese toxicity.BMC genomics · 2020Article
- Mechanism for Higher Tolerance to and Lower Accumulation of Arsenite inPlants (Basel, Switzerland) · 2020Article
- Development of a DNA-based real-time PCR assay for the quantification ofPlant methods · 2020Article
- Advances in the Mechanisms of Plant Tolerance to Manganese Toxicity.International journal of molecular sciences · 2019Review
- Article
- Genome-Wide Identification and Expression Analysis of the Cation Diffusion Facilitator Gene Family in Turnip Under Diverse Metal Ion Stresses.Frontiers in genetics · 2018Article
- OsMTP11 is localised at the Golgi and contributes to Mn tolerance.Scientific reports · 2017Article
- Reliable reference genes for normalization of gene expression data in tea plants (Camellia sinensis) exposed to metal stresses.PloS one · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese (Mn) is an important micronutrient element required for plant growth and development, playing catalytic roles in enzymes, membranes and DNA replication. The tea plant (Camellia sinensis) is able to accumulate high concentration of Mn without showing signs of toxicity, but the molecular mechanisms underlying this remain largely unknown. In this study, the C. sinensis cultivar 'LJCY' had higher Mn tolerance than cultivar 'YS', because chlorophyll content reduction was lower under the high Mn treatment. Proteomic analysis of the leaves revealed that C. sinensis Metal Tolerance Protein 8 (CsMTP8) accumulated in response to Mn toxicity in cultivar 'LJCY'. The gene encoding CsMTP8, designated as CsMTP8 was also isolated, and its expression enhanced Mn tolerance in Saccharomyces cerevisiae. Similarly, the overexpression of CsMTP8 in Arabidopsis thaliana increased plant tolerance and reduced Mn accumulation in plant tissues under excess Mn conditions. Subcellular localization analysis of green florescence fused protein indicated that CsMTP8 was localized to the plasma membranes. Taken together, the results suggest that CsMTP8 is a Mn-specific transporter, which is localized in the plasma membrane, and transports excess Mn out of plant cells. The results also suggest that it is needed for Mn tolerance in shoots.
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