ArticleScientific reports2017
Topological transformations in proteins: effects of heating and proximity of an interface.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- AnFrontiers in chemistry · 2026Article
- Clustering-based Method for Constructing the Phase Diagram of the van der Waals Model Fluid.Current protein & peptide science · 2025Article
- Treatment of flexibility of protein backbone in simulations of protein-ligand interactions using steered molecular dynamics.Scientific reports · 2024Article
- Theoretical framework and experimental solution for the air-water interface adsorption problem in cryoEM.Biophysics reports · 2023Article
- The coexistence region in the Van der Waals fluid and the liquid-liquid phase transitions.Frontiers in chemistry · 2022Article
- To Tie or Not to Tie? That Is the Question.Polymers · 2017Review
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Authors and funding
3 authors.
Funding
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Abstract
Using a structure-based coarse-grained model of proteins, we study the mechanism of unfolding of knotted proteins through heating. We find that the dominant mechanisms of unfolding depend on the temperature applied and are generally distinct from those identified for folding at its optimal temperature. In particular, for shallowly knotted proteins, folding usually involves formation of two loops whereas unfolding through high-temperature heating is dominated by untying of single loops. Untying the knots is found to generally precede unfolding unless the protein is deeply knotted and the heating temperature exceeds a threshold value. We then use a phenomenological model of the air-water interface to show that such an interface can untie shallow knots, but it can also make knots in proteins that are natively unknotted.
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