Evidence map›Paper›PMID 28051069›Full record

ArticleScientific reports2017

A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System.

Shengyong Geng, Yuzhu Wang, Liping Wang, Tsutomu Kouyama, Toshiaki Gotoh, Satoshi Wada, Jin-Ye Wang

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Light-responsive biomaterials for ocular drug delivery.Drug delivery and translational research · 2023
    Review
  6. Article
  7. Article
  8. Lipid-Based Nanovesicular Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Self-Assembly of Photoresponsive Molecular Amphiphiles in Aqueous Media.Angewandte Chemie (International ed. in English) · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Membrane Environment Enables Ultrafast Isomerization of Amphiphilic Azobenzene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shengyong GengSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Yuzhu WangShanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China.
Liping WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Tsutomu KouyamaDepartment of Physics, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Toshiaki GotohDepartment of Physics, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Satoshi WadaPhotonics Control Technology Team, Advanced Photonics Technology Development Group, Center for Advanced Photonics, RIKEN, Wako, Saitama 351-0198, Japan.
Jin-Ye WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structure of a self-assembly formed from a cationic azobenzene derivative, 4-cholesterocarbonyl-4'-(N,N,N-triethylamine butyloxyl bromide) azobenzene (CAB) and surfactant sodium dodecyl sulfate (SDS) in aqueous solution was studied by cryo-TEM and synchrotron radiation small-angle X-ray scattering (SAXS). Both unilamellar and multilamellar vesicles could be observed. CAB in vesicles were capable to undergo reversible trans-to-cis isomerization upon UV or visible light irradiation. The structural change upon UV light irradiation could be catched by SAXS, which demonstrated that the interlamellar spacing of the cis-multilamellar vesicles increased by 0.2-0.3 nm. Based on this microstructural change, the release of rhodamine B (RhB) and doxorubicin (DOX) could be triggered by UV irradiation. When incubated NIH 3T3 cells and Bel 7402 cells with DOX-loaded CAB/SDS vesicles, UV irradiation induced DOX release decreased the viability of both cell lines significantly compared with the non-irradiated cells. The in vitro experiment indicated that CAB/SDS vesicles had high efficiency to deliver loaded molecules into cells. The in vivo experiment showed that CAB/SDS vesicles not only have high drug delivery efficiency into rat retinas, but also could maintain high drug concentration for a longer time. CAB/SDS catanionic vesicles may find potential applications as a smart drug delivery system for controlled release by light.

Indexed as

Drug Delivery SystemsLightUltraviolet RaysAnimalsAntineoplastic AgentsAzo CompoundsCell LineCryoelectron MicroscopyDoxorubicinFluorescent DyesHumansMiceRhodaminesScattering, Small AngleSodium Dodecyl SulfateAntineoplastic AgentsazobenzeneAzo CompoundsDoxorubicinFluorescent Dyesrhodamine BRhodaminesSodium Dodecyl Sulfate

Identifiers

PMID28051069
PMCPMC5209711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.