ArticleDiagnostic and interventional radiology (Ankara, Turkey)
Comparison of biexponential and monoexponential DWI in evaluation of Fuhrman grading of clear cell renal cell carcinoma.
Article in Diagnostic and interventional radiology (Ankara, Turkey). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Diagnostic test accuracy of ADC values for identification of clear cell renal cell carcinoma: systematic review and meta-analysis.European radiology · 2020Pooled it
- Quantitative MRI for World Health Organisation/International Society of Urological Pathology Grading of Renal Cell Carcinoma: a systematic review and diagnostic meta-analysis.European radiology · 2026Article
- Grading of clear cell renal cell carcinoma using diffusion MRI with a multimodal apparent diffusion model.Frontiers in oncology · 2025Article
- Development and validation of intravoxel incoherent motion diffusion weighted imaging-based model for preoperative distinguishing nuclear grade and survival of clear cell renal cell carcinoma complicated with venous tumor thrombus.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Grading of clear cell renal cell carcinoma by using monoexponential, biexponential, and stretched exponential diffusion-weighted MR imaging.Frontiers in oncology · 2024Article
- Comparative study of conventional diffusion-weighted imaging and introvoxel incoherent motion in assessment of pathological grade of clear cell renal cell carcinoma.The British journal of radiology · 2022Article
- The diagnostic utility of diffusion weighted MRI imaging and ADC ratio to distinguish benign from malignant renal masses: sorting the kittens from the tigers.BMC urology · 2021Article
- Application of diffusion kurtosis tensor MR imaging in characterization of renal cell carcinomas with different pathological types and grades.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Renal Diffusion-Weighted Imaging in Healthy Dogs: Reproducibility, Test-Retest Repeatability, and Selection of the Optimal b-value Combination.Frontiers in veterinary science · 2021Article
- Differentiating between malignant and benign renal tumors: do IVIM and diffusion kurtosis imaging perform better than DWI?European radiology · 2019Article
- Comparison of Monoexponential, Biexponential, Stretched-Exponential, and Kurtosis Models of Diffusion-Weighted Imaging in Differentiation of Renal Solid Masses.Korean journal of radiology · 2019Article
- Discrimination of oncocytoma and chromophobe renal cell carcinoma using MRI.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
- Diffusion-weighted MRI in the evaluation of the thyroid nodule: Comparison between integrated-shimming EPI and conventional 3D-shimming EPI techniques.Oncotarget · 2018Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClear cell renal cell carcinoma (ccRCC) is the most common primary malignant urologic tumor. The Fuhrman grading system is an independent indicator for aggressiveness and prognosis of ccRCC. We aimed to assess the possible diagnostic role of biexponentially and monoexponentially fitted signal attenuation for the Fuhrman grading.
methodsA total of 33 patients with ccRCC underwent multiple b values (0, 20, 50, 100, 150, 250, 400, 600, 800, 1000 s/mm2) diffusion-weighted imaging (DWI). Biexponential parameters (fast ADC [ADCf], slow ADC [ADCs], and fraction of ADCf [f]) and monoexponential apparent diffusion coefficient were calculated, and correlated with the Fuhrman grade of ccRCC respectively. The performance of biexponential parameters in differentiating Fuhrman low- and high-grade tumors was assessed and compared with ADC value by receiver operating characteristic analysis.
resultsQualified images and diffusion-weighted parameters were obtained for all patients. The ADCf and f value were positively correlated, whereas ADCs and ADC value were negatively correlated with Fuhrman grade. Significant differences were observed in ADCf (P < 0.001), ADCs (P = 0.005), and f values (P < 0.001) of high- and low-grade ccRCCs. When differentiating Fuhrman low-grade tumors from high-grade, the ADCf revealed an area under receiver operating characteristic curve of 0.959, which was higher than the ADC value (0.789; P = 0.046), while ADCs (0.807) and f (0.833) showed no significant difference from ADC (P = 0.85 for ADCs, P = 0.73 for f).
conclusionBiexponential DWI provides additional parameters for ccRCC. ADCf is more accurate compared with the ADC value in characterizing Fuhrman grade of ccRCC.
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