Evidence map›Paper›PMID 28050886›Full record

ArticleJournal of community genetics2017

Evaluation of cortisol and telomere length measurements in ethnically diverse women with breast cancer using culturally sensitive methods.

Julio Ramirez, May Elmofty, Esperanza Castillo, Mindy DeRouen, Salma Shariff-Marco, Laura Allen, Scarlett Lin Gomez, Anna María Nápoles, Leticia Márquez-Magaña

Open access · hybridAbstract read
In one paragraph

Article in Journal of community genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Nativity and Healthy Lifestyle Index in a Pooled Cohort of Female Breast Cancer Survivors from Northern California.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  11. Collecting Hair Samples for Hair Cortisol Analysis in African Americans.Journal of visualized experiments : JoVE · 2018
    Article
  12. Article
  13. Telomere Homeostasis: Interplay with Magnesium.International journal of molecular sciences · 2018
    Review
  14. Healthy Parks Healthy People as an Upstream Stress Reduction Strategy.Recreation, parks, and tourism in public health · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Julio RamirezHealth Equity Research Laboratory, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA.
May ElmoftyHealth Equity Research Laboratory, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA.
Esperanza CastilloHealth Equity Research Laboratory, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA.
Mindy DeRouenCancer Prevention Institute of California, 2201 Walnut Avenue, Suite #300, Fremont, CA, 94538, USA.
Salma Shariff-MarcoCancer Prevention Institute of California, 2201 Walnut Avenue, Suite #300, Fremont, CA, 94538, USA.
Laura AllenCancer Prevention Institute of California, 2201 Walnut Avenue, Suite #300, Fremont, CA, 94538, USA.
Scarlett Lin GomezCancer Prevention Institute of California, 2201 Walnut Avenue, Suite #300, Fremont, CA, 94538, USA.
Anna María NápolesCenter for Aging in Diverse Communities, Division of General Internal Medicine, Department of Medicine and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA.
Leticia Márquez-MagañaHealth Equity Research Laboratory, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA. marquez@sfsu.edu.
San Francisco State University · USStanford University · USCancer Prevention Institute of California · USUniversity of California, San Francisco · US

Funding

RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEAH S KARLINER · 1997 to 2026
$19.5M
SF BUILD: Enabling Students to Represnt in ScienceUL1GM118985 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$18.2M
SF BUILD: Enabling Students to Represent in ScienceTL4GM118986 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2022
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
NIA NIH HHS P30 AG015272NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS TL4 GM118986NIGMS NIH HHS UL1 GM118985
6 · The paper itself

Abstract

The under-representation of ethnic minority participants, who are more likely to be socially disadvantaged in biomedical research, limits generalizability of results and reductions in health disparities. To facilitate investigations of how social disadvantage "gets under the skin," this pilot study evaluated low-intensity methods for collecting hair and saliva samples from multiethnic breast cancer survivors (N = 70) and analysis of biomarkers of chronic stress (cortisol levels) and biological age (telomere length). Methods allowed for easy self-collection of hair (for cortisol) and saliva (for telomere lengths) samples that were highly stable for shipment and long-term storage. Measuring cortisol in hair as a biomarker of chronic stress was found to overcome many of the limitations of salivary cortisol measurements, and the coefficient of variation obtained using an ELISA-based approach to measure cortisol was within acceptable standards (16%). Telomere length measurements obtained using a qPCR approach had a coefficient of variation of <10% when the DNA extracted from the saliva biospecimens was of sufficient quantity and quality (84%). The overall response rate was 47%; rates were 32% for African-Americans, 39% for Latinas, 40% for Asians, and 82% for non-Latina Whites. Self-collection of hair and saliva overcame cultural and logistical barriers associated with collection of blood. Results support the use of these biospecimen collection and analysis methods among ethnically diverse and disadvantaged populations to identify biopsychosocial pathways of health disparities. Our tools should stimulate research to better understand how social disadvantage "gets under the skin" and increase participation of ethnic minorities in biomedical research.

Indexed as

BiospecimensCortisol levelsEthnic minority populationsTelomere length

Identifiers

PMID28050886
PMCPMC5386910
OpenAlexW2561151492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.