ArticleAMB Express2017
Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei.
Article in AMB Express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 61 citations in OpenAlex.
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- Bacillus aryabhattai CKNJh11 as a promising probiotic improves growth performance and egg quality in laying hens.Scientific reports · 2025Article
- Whole genome-sequence analysis of Bacillus subtilis strain KC14-1 with broad-spectrum antifungal activity.BMC genomics · 2025Article
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- Rational design of an acidic erythritol (ACER) medium for the enhanced isolation of the environmental pathogenFrontiers in microbiology · 2023Article
- Antagonistic activity ofCurrent research in microbial sciences · 2023Article
- Genomic insights into antimicrobial potential and optimization of fermentation conditions of pig-derivedFrontiers in microbiology · 2023Article
- Molecular Characterization and Diversity of Bacteria Isolated from Fish and Fish Products Retailed in Kenyan Markets.International journal of food science · 2022Article
- Identification of a New Antifungal Peptide W1 From a MarineFrontiers in microbiology · 2022Article
- Digyalipopeptide A, an antiparasitic cyclic peptide from the GhanaianBeilstein journal of organic chemistry · 2022Article
- The Burkholderia pseudomalleiMicrobiology spectrum · 2021Article
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- Deciphering theFrontiers in microbiology · 2021Article
- Effectiveness of3 Biotech · 2019Article
- Antibacterial activity of soil bacteria isolated from Kochi, India and their molecular identification.Journal, genetic engineering & biotechnology · 2018Article
- Burkholderia pseudomallei-absent soil bacterial community results in secondary metabolites that kill this pathogen.AMB Express · 2018Article
- Transmission Modes of Melioidosis in Taiwan.Tropical medicine and infectious disease · 2018Review
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus species are Gram-positive bacteria found in abundance in nature and their secondary metabolites were found to possess various potential activities, notably antimicrobial. In this study, Bacillus amyloliquefaciens N2-4 and N3-8 were isolated from soil and their metabolites could kill Burkholderia pseudomallei, a Gram-negative pathogenic bacterium also found in soil in its endemic areas. Moreover, the metabolites were able to kill drug resistant isolates of B. pseudomallei and also inhibit other pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Acinetobacter baumannii but not the non-pathogenic Burkholderia thailandensis, which is closely related to B. pseudomallei. Since the antimicrobial activity of N3-8 was not partially decreased or abolished when treated with proteolytic enzymes or autoclaved, but N2-4 was, these two strains should have produced different compounds. The N3-8 metabolites with antimicrobial activity consisted of both protein and non-protein compounds. The inhibition spectrum of the precipitated proteins compared to the culture supernatant indicated a possible synergistic effect of the non-protein and peptide compounds of N3-8 isolates against other pathogens. When either N2-4 or N3-8 isolates was co-cultured with B. pseudomallei the numbers of the bacteria decreased by 5 log
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