ArticleIrish journal of medical science2017
Radiotherapy for the treatment of thyroid eye disease-a prospective comparison: Is orbital radiotherapy a suitable alternative to steroids?
Article in Irish journal of medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Clinical study of thyroid eye disease combined with myasthenia gravis.Japanese journal of ophthalmology · 2025Article
- Review
- The efficacy of radiotherapy for steroid-resistant thyroid eye disease: clinical outcomes in orbital inflammation and exophthalmos.Radiation oncology journal · 2025Article
- Article
- Optimal timing for cataract surgery in patients with thyroid-associated ophthalmopathy.International journal of ophthalmology · 2025Article
- Combining orbital intensity modulated radiation therapy with periorbital triamcinolone acetonide injection for Graves' orbitopathy.International journal of ophthalmology · 2025Article
- A retrospective study on the effectiveness of intensity modulated radiation therapy for thyroid associated ophthalmopathy at a single institute.Scientific reports · 2024Article
- Future Projections in Thyroid Eye Disease.The Journal of clinical endocrinology and metabolism · 2022Review
- Improvement of the MRI and clinical features of Asian Graves' ophthalmopathy by radiation therapy with steroids.Japanese journal of radiology · 2019Article
- Interruption of autoimmunity for thyroid eye disease: B-cell and T-cell strategy.Eye (London, England) · 2019Article
- Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves' Ophthalmopathy: Good Results After Long-Term Follow-Up.International journal of endocrinology and metabolism · 2019Article
- Orbital radiotherapy plus three-wall orbital decompression in a patient with rare ocular manifestations of thyroid eye disease: case report.BMC endocrine disorders · 2018Article
- Role of concurrent intravenous pulse steroids and orbital radiation in the management of thyroid eye disease.Oman journal of ophthalmologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsTo evaluate the efficacy of orbital radiotherapy (OR) for the treatment of thyroid eye disease (TED).
methodsThirty-five consecutive patients with active TED with contraindications to steroid therapy received a course of OR. Bilateral retrobulbar irradiation was performed with a total dose of 20 Gy. 7-points clinical activity score (7-CAS), ocular motility, visual acuity (VA), exophthalmos and eyelid retraction were prospectively evaluated at 3, 6 and 12 months and compared with baseline data.
resultsThere was a statistically significant improvement in 7-CAS at 3, 6 and 12 months post-treatment (p < 0.05). Ocular motility disturbances improved at 6 and 12 months (p < 0.05). Visual acuity remained stable; there was no significant change in exophthalmos (mean 24 mm, SD 3 mm) or eyelid retraction (marginal reflex distance mean 6 mm, SD 1.5 mm) during the follow-up period. No side effects were registered.
conclusionsThis study suggests that OR might be effective in reducing 7-CAS and ocular motility disturbances. No significant improvement in proptosis or eyelid retraction should be expected from this treatment. OR might be considered a suitable alternative treatment in TED for patients who cannot tolerate steroids.
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