Evidence map›Paper›PMID 28050786›Full record

Observational studyDigestive diseases and sciences2017

Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users.

Yoshiyasu Kono, Minoru Matsubara, Tatsuya Toyokawa, Ryuta Takenaka, Seiyu Suzuki, Junichirou Nasu, Masao Yoshioka, Masahiro Nakagawa, Motowo Mizuno, Hiroyuki Sakae and 11 more

Erratum issuedAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 1 country.

Yoshiyasu KonoDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. hxnwq178@yahoo.co.jp.
Minoru MatsubaraDepartment of Internal Medicine, Sumitomo Bessi Hospital, Niihama, 792-8543, Japan.
Tatsuya ToyokawaDepartment of Gastroenterology, National Hospital Organization, Fukuyama Medical Center, Fukuyama, 720-8520, Japan.
Ryuta TakenakaDepartment of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, 708-0841, Japan.
Seiyu SuzukiDepartment of Internal Medicine, Sumitomo Bessi Hospital, Niihama, 792-8543, Japan.
Junichirou NasuDepartment of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, 700-8551, Japan.
Masao YoshiokaDepartment of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, 700-8551, Japan.
Masahiro NakagawaDepartment of Internal Medicine, Hiroshima City Hospital, Hiroshima, 730-8518, Japan.
Motowo MizunoDepartment of Internal Medicine, Hiroshima City Hospital, Hiroshima, 730-8518, Japan.
Hiroyuki SakaeDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Makoto AbeDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Tatsuhiro GotodaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Ko MiuraDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Hiromitsu KanzakiDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Masaya IwamuroDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Keisuke HoriDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Takao TsuzukiDepartment of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, 670-8540, Japan.
Masahide KitaDepartment of Internal Medicine, Okayama City Hospital, Okayama, 700-0833, Japan.
Seiji KawanoDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Yoshiro KawaharaDepartment of Endoscopy, Okayama University Hospital, Okayama, 700-8558, Japan.
Hiroyuki OkadaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Okayama University · JPHiroshima Prefectural Hospital · JPOkayama Saiseikai General Hospital · JPSumitomo Besshi Hospital · JPFukuyama Cardiovascular Hospital · JPHimeji Red Cross Hospital · JPOkayama Prefecture · JPOkayama University Hospital · JPTsuyama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Japan Gastroenterological Endoscopy Society updated its guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment in July 2012. However, the safety of endoscopic procedures in antithrombotic drug users has not been fully investigated.

aimsTo evaluate the safety of upper gastrointestinal endoscopic procedures in antithrombotic drug users.

methodsFrom September 2013 to September 2015, patients who were taking antithrombotic drugs and who underwent upper gastrointestinal endoscopic procedures were prospectively enrolled at five hospitals. Incidences of bleeding and thrombosis during endoscopic procedures were evaluated.

resultsA total of 270 patients [221 for endoscopic mucosal biopsy and 49 for endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD) were enrolled. The bleeding rate was 0.9% for endoscopic mucosal biopsy and 22% for EMR/ESD, respectively. The bleeding rate after endoscopic mucosal biopsy was not significantly high, even if antithrombotic drugs were continued (0 vs. 1%, P > 0.99), while it was significantly higher among multiple antithrombotic drug users than single drug users (5.9 vs. 0%, P < 0.05). The bleeding rate after EMR/ESD was also higher among multiple antithrombotic drug users than single drug users, but was not significantly different (33 vs. 14%, P = 0.17). Moreover, there were no differences in bleeding rates according to the cessation or continuance of antithrombotic drugs (20 vs. 25%, P = 0.74). There were no thromboembolisms in all cases.

conclusionsUpper gastrointestinal endoscopic procedures performed under the new guidelines appear acceptable. However, endoscopic procedures among multiple antithrombotic drug users show a greater potential for bleeding.

Indexed as

Endoscopic Mucosal ResectionIntraoperative ComplicationsAgedAged, 80 and overBiopsyFemaleFibrinolytic AgentsGastrointestinal HemorrhageGastrointestinal NeoplasmsHelicobacter InfectionsHumansIncidenceJapanMaleMiddle AgedProspective StudiesFibrinolytic AgentsAntithrombotic drugEndoscopyGuidelinesHemorrhageThromboembolism

Identifiers

PMID28050786
OpenAlexW2564183263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.