ArticleDigestive diseases and sciences2017
Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis.
Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.United European gastroenterology journal · 2025Guideline
- Cyclic Vomiting Syndrome in Children.Frontiers in neurology · 2020Pooled it
- Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association.Neurogastroenterology and motility · 2019Guideline
- Clinical Characteristics and Associated Factors in Mexican Patients With Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome.Journal of neurogastroenterology and motility · 2025Article
- Impact of Opioid and Cannabis Use on Low-Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real-World Study in the United Kingdom.Neurogastroenterology and motility · 2025Article
- Treatment principles in adults and development of patient-reported outcomes in cyclic vomiting syndrome.Neurogastroenterology and motility · 2025Review
- Acute care of cyclic vomiting syndrome and cannabinoid hyperemesis syndrome in the home and emergency department.Neurogastroenterology and motility · 2025Review
- Endocannabinoid signaling in stress, nausea, and vomiting.Neurogastroenterology and motility · 2025Review
- Utility of Aprepitant in the Management of Pediatric Patients with Cyclical Vomiting Syndrome.Medicines (Basel, Switzerland) · 2024Article
- Percutaneous electrical nerve field stimulation improves comorbidities in children with cyclic vomiting syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Review
- Cyclic Vomiting Syndrome-Related Hospitalizations Trends, Comorbidities & Health Care Costs in Children: A Population Based Study.Children (Basel, Switzerland) · 2022Article
- Health Care Resource Use and Associated Costs of Cyclic Vomiting Syndrome in the United States.Gastro hep advances · 2022Article
- Productivity Loss and Indirect Burden of Cyclic Vomiting Syndrome in the United States.Gastro hep advances · 2022Article
- Article
- Cyclic vomiting syndrome in children.Canadian family physician Medecin de famille canadien · 2021Article
- A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection.Headache · 2021Review
- Highly effective use of aprepitant in an adolescent girl with severe cyclic vomiting syndrome.BMJ case reports · 2021Article
- Prevalence of cannabis use has significantly increased in patients with cyclic vomiting syndrome.Neurogastroenterology and motility · 2020Article
- Highlighting the importance of early diagnosis of cyclic vomiting syndrome in adults: A case report.Medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale.
aimTo study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database.
methodsWe identified all hospitalizations associated with a primary diagnosis of CVS in 2010 and 2011 using the Nationwide Inpatient Sample with an age category of 18-55 years. A 1:2 random sample of non-CVS hospitalizations with the same age category was obtained, and comparisons between groups were made. Multivariate logistic regression analysis was used to determine comorbidities independently associated with CVS.
resultsOur study included 20,952 CVS and 44,262 non-CVS patients. CVS patients tended to be younger, male, and white compared to non-CVS patients. On multivariate analysis, CVS was significantly associated with comorbidities including dysautonomia, migraine, anxiety, marijuana use, irritable bowel syndrome, gastroparesis, gastroesophageal reflux disease, asthma, cigarette smoking, and hypertension. CVS patients underwent esophagogastroduodenoscopy, colonoscopy, and gastric emptying tests more frequently. They had more favorable hospital outcomes like more routine discharges (discharge to home/self-care), lower mortality, and shorter length of stay but tended to leave against medical advice more frequently. CVS patients incurred total hospital charges of about $400 million over the 2 years.
conclusionsOur study showed that CVS is associated with several comorbidities and incurred substantial health care costs despite benign outcomes. Efforts to optimize therapy of CVS, manage comorbid conditions and reduce healthcare utilization are warranted.
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