Observational studyWorld journal of surgery2017
Rifampicin for Idiopathic Granulomatous Lobular Mastitis: A Promising Alternative for Treatment.
Observational study in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Risk factors for non-puerperal mastitis: a meta-analysis.BMC women's health · 2025Pooled it
- Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- A meta-analysis of idiopathic granulomatous mastitis treatments for remission and recurrence prevention.Frontiers in medicine · 2024Pooled it
- Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis: A Systematic Review.The breast journal · 2023Pooled it
- Microwave Ablation for Granulomatous Lobular Mastitis: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Trimethoprim-Sulfamethoxazole in the Treatment of Idiopathic Granulomatous Mastitis: A Retrospective Cohort Study.Health science reports · 2026Article
- Article
- Development and Internal Validation of a Clinical Data-Based Machine Learning Web Calculator for Predicting Recurrence in Granulomatous Lobular Mastitis: A Multicenter Retrospective Study.European journal of breast health · 2026Article
- Detection ofVeterinary sciences · 2026Article
- Effects of lipid-lowering drug on vancomycin-sensitive Corynebacterium kroppenstedtii.BMC microbiology · 2026Article
- Management of Idiopathic Granulomatous Mastitis: Effectiveness of a Steroid-Free Regimen UsingThe breast journal · 2025Article
- Idiopathic Granulomatous Mastitis: Immune-Pathogen Imbalance in a Treatment-Resistant Benign Inflammatory Disease.International journal of women's health · 2025Review
- Analysis of three treatment methods for granulomatous lobular mastitis: a retrospective study in a single center.Frontiers in oncology · 2025Article
- Clinical characteristics of patients with granulomatous lobular mastitis associated with Corynebacterium parakroppenstedtii infection and drug sensitivity analysis of the isolated strains.Annals of clinical microbiology and antimicrobials · 2024Article
- Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis.Signal transduction and targeted therapy · 2024Article
- Periductal Mastitis, a Disease with Distinct Clinicopathological Features from Granulomatous Lobular Mastitis.Journal of inflammation research · 2024Article
- Dermis-retained breast dermo-glandular flap: a new surgical approach for granulomatous lobular mastitis.Frontiers in surgery · 2023Article
- Management of Granulomatous Lobular Mastitis and Risk Factors Associated with Recurrence.World journal of surgery · 2022Article
- Tissue proteome analysis revealed an association between cancer, immune system response, and the idiopathic granulomatous mastitis.Medical oncology (Northwood, London, England) · 2022Article
- Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition).Military Medical Research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic granulomatous lobular mastitis (IGLM) is a chronic, non-caseating, inflammatory breast disease of obscure aetiology characterized by multiple masses, abscesses and sinus formation. There is no standard treatment to date, but surgical procedures and systemic corticosteroids are effective in its treatment despite high recurrence rates. PATIENTS AND
methodsThis prospective study including 30 patients with IGLM between November 2012 and May 2016 aimed to investigate the possibility of administration of Rifampicin (300 mg twice daily for a period of 6-9 months) as an alternative therapy for both surgery and corticosteroids in patients with IGLM. All patients were diagnosed by core needle biopsy.
resultsAll patients were of reproductive age and had a history of breast feeding, which is the most important predisposing factor for IGLM. The mean age was 31.6 ± 5.8 years (range 23-42 years). Eighteen patients (60%) were treated by Rifampicin for 6 months, whereas 12 patients (40%) were treated for 9 months. Twelve months after the beginning of therapy, all patients showed complete clinical and ultrasonographic responses. No serious side effects were reported to stop the treatment course. The median follow-up after finishing the course of treatment was 15.5 months (average 3-35 months) with no episodes of disease relapse.
conclusionRifampicin is effective in the treatment of patients with IGLM with complete clinical and ultrasonographic response after 6-9 months and could be used as a solo medical therapy alternative to both surgery and corticosteroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.