Evidence map›Paper›PMID 28050656›Full record

ReviewJournal of neurology2017

The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension.

Christopher H Gibbons, Peter Schmidt, Italo Biaggioni, Camille Frazier-Mills, Roy Freeman, Stuart Isaacson, Beverly Karabin, Louis Kuritzky, Mark Lew, Phillip Low and 4 more

3 registry-linked trialsOpen access · hybridAbstract readConsensus StatementReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 216 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 9 pooled it
39.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05400174 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2021 to 2027Enrolled60ConditionsParkinson Disease, Orthostatic Hypotension, DysautonomiaArmsTilt table (upright position)
NCT06072105 narecruitingnot on this mapstarted 2023, after this paper: background citation

Medical Decision Making in Multiple System Atrophy: Developing Personalized Best Medical Care with Integrated Telemedicine and Mobile Palliative Care for Individuals with Multiple System Atrophy

TypeinterventionalSponsorMedical University InnsbruckRan2023 to 2027Enrolled92ConditionsMultiple System AtrophyArmsTelemedicine visits, Multidisciplinary, personalized symptomatic treatment
NCT06252376 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in Parkinson's Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2029Enrolled0ConditionsParkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive ImpairmentArmsHead-up tilt table
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 9 syntheses or guidelines pooled it, 432 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Fludrocortisone for orthostatic hypotension.The Cochrane database of systematic reviews · 2021
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Trial
  14. Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Trial
  15. Trial
  16. Trial
  17. Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension.Annals of clinical and translational neurology · 2020
    Trial
  18. Trial
  19. Orthostatic hypotension and acute cognitive dysfunction in Parkinson's disease: insights from functional near-infrared spectroscopy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  20. Long-term outcomes of hyperadrenergic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 14 institutions in 2 countries.

Christopher H GibbonsHarvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA. cgibbons@bidmc.harvard.edu.
Peter SchmidtNational Parkinson Foundation, Miami, FL, USA.
Italo BiaggioniVanderbilt University Medical Center, Nashville, TN, USA.
Camille Frazier-MillsDuke University Hospital and Central Carolina Hospital, Durham, NC, USA.
Roy FreemanHarvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Stuart IsaacsonParkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, USA.
Beverly KarabinUniversity of Toledo Medical Center, Toledo, OH, USA.
Louis KuritzkyUniversity of Florida College of Medicine, Gainesville, FL, USA.
Mark LewKeck/USC School of Medicine, Los Angeles, CA, USA.
Phillip LowMayo Clinic, Rochester, MN, USA.
Ali MehdiradSaint Louis University Hospital, St. Louis, MO, USA.
Satish R RajUniversity of Calgary, Calgary, BC, Canada.
Steven VerninoUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Horacio KaufmannNew York University Langone Medical Center, New York, NY, USA.
Beth Israel Deaconess Medical Center · USDuke University Hospital · USFlorida College · USHarvard University · USKeck Hospital of USC · USMayo Clinic in Arizona · USNYU Langone Health · USParkinson's Foundation · USParkinson's Research and Education Foundation · USSaint Louis University Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Calgary · CAUniversity of Toledo Medical Center · USVanderbilt University Medical Center · US

Funding

Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, ROY · 2009 to 2018
$11.6M
NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension. To address these issues, the American Autonomic Society and the National Parkinson Foundation initiated a project to develop a statement of recommendations beginning with a consensus panel meeting in Boston on November 7, 2015, with continued communications and contributions to the recommendations through October of 2016. This paper summarizes the panel members' discussions held during the initial meeting along with continued deliberations among the panel members and provides essential recommendations based upon best available evidence as well as expert opinion for the (1) screening, (2) diagnosis, (3) treatment of nOH, and (4) diagnosis and treatment of associated supine hypertension.

Indexed as

HumansHypertensionHypotension, OrthostaticSupine PositionAutonomic dysfunctionDroxidopaFludrocortisoneMidodrineNeurogenic orthostatic hypotensionSupine hypertension

Identifiers

PMID28050656
PMCPMC5533816
OpenAlexW2567578155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.