ArticleEuropean journal of nuclear medicine and molecular imaging2017
Myocardial blood flow and left ventricular functional reserve in hypertrophic cardiomyopathy: a
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Myocardial Perfusion Imaging with Cardiovascular Magnetic Resonance in Nonischemic Cardiomyopathies: An In-Depth Review of Techniques and Clinical Applications.Medicina (Kaunas, Lithuania) · 2025Review
- The Utility of Nuclear Imaging in Hypertrophic Cardiomyopathy: A Narrative Review.Journal of clinical medicine · 2025Review
- Subclinical myocardial dysfunction assessed by cardiac magnetic resonance feature tracking predicts ventricular arrhythmias in early-stage hypertension.Frontiers in cardiovascular medicine · 2025Article
- Reduction in myofilament CaFrontiers in physiology · 2025Article
- Advances in Multi-Modality Imaging in Hypertrophic Cardiomyopathy.Journal of clinical medicine · 2024Review
- Mexican guidelines 2024 for the diagnosis and treatment of hypertrophic cardiomyopathy.Archivos de cardiologia de Mexico · 2024Article
- Coronary microvascular disease in hypertrophic and infiltrative cardiomyopathies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Evaluation of the diagnostic value of joint PET myocardial perfusion and metabolic imaging for vascular stenosis in patients with obstructive coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3DEuropean journal of nuclear medicine and molecular imaging · 2021Article
- Tricked by transient ischemic dilation: A case of hypertrophic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Transient ischemic dilation in hypertrophic cardiomyopathy: A complex sign in a complex disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Sub-endocardial and sub-epicardial measurement of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Observational
- Right atrial function assessed by volume-derived values and speckle tracking echocardiography in patients with hypertrophic cardiomyopathy.BMC cardiovascular disorders · 2020Article
- Adding clinical value with coronary flow assessment in hypertrophic obstructive cardiomyopathy.International journal of cardiology. Heart & vasculature · 2020Article
- Positron emission tomography (International journal of cardiology. Heart & vasculature · 2020Article
- Microvascular Angina Diagnosed by Absolute PET Myocardial Blood Flow Quantification.Current cardiology reports · 2020Review
- Novel 3D heart left ventricle muscle segmentation method for PET-gated protocol and its verification.Annals of nuclear medicine · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIschemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF) reserve in HCM patients undergoing dipyridamole (Dip) PET.
methodsResting and stress
resultsEighteen patients had preserved (group A) and 16 abnormal LVEF reserve (group B; range -7 to -32). Group B patients had greater wall thickness than group A, but resting volumes, LVEF, resting and Dip MBF, and myocardial flow reserve were similar. Group B had slightly higher summed stress score and summed difference score in visual analysis than group A, and a significantly higher summed stress wall motion score. In group B, resting TPG was slightly lower (1.31 ± 0.29 vs. 1.37 ± 0.34, p <0.05), and further decreased after Dip, whilst in group A it increased (B = 1.20 ± 0.39, p < 0.0001 vs. rest and vs. A = 1.40 ± 0.43). The number of segments per patient with TPG <1 was higher than in group A (p < 0.001) and was a significant predictor of impaired LVEF reserve (OR 1.86, p < 0.02), together with wall thickness (OR 1.3, p < 0.02).
conclusionAbnormal LVEF response is common in HCM patients following Dip, and is related to abnormal TPG, suggesting that subendocardial ischemia might occur under Dip and cause transient LV dysfunction. Although in vivo this effect may be hindered by the adrenergic drive associated with effort, these findings may have relevance in understanding exercise limitation and heart failure symptoms in HCM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.