ReviewPsychopharmacology2017
Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction.
Review in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Automated Facial Emotion Recognition System Detects Altered Emotional Processing During Craving Induction in Individuals with Substance Use Disorder.Healthcare (Basel, Switzerland) · 2026Article
- From Neuroadaptation to Neuroprogression: Rethinking Chronic Cocaine Exposure Through a Model of Cocaine-Related Cerebropathy.Journal of clinical medicine · 2026Article
- A history of addiction through the six editions of Kandel'sFrontiers in behavioral neuroscience · 2026Review
- Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats.Addiction biology · 2023Article
- Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism.Brain sciences · 2023Review
- Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.International journal of molecular sciences · 2023Review
- Interaction effects between smoking and internet gaming disorder on resting-state functional connectivity of the ventral tegmental area and hippocampus.Frontiers in neuroscience · 2023Article
- Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats.Frontiers in pharmacology · 2023Article
- Kappa opioid receptor antagonism protects working memory performance from mild stress exposure in Rhesus macaques.Neurobiology of stress · 2022Article
- Co-Occurring Obsessive-Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities.Archives of sexual behavior · 2022Article
- NPsychopharmacology · 2022Article
- Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.Frontiers in cellular neuroscience · 2022Article
- Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders.Current topics in behavioral neurosciences · 2022Review
- Demand for fentanyl becomes inelastic following extended access to fentanyl vapor self-administration.Neuropharmacology · 2021Article
- Individual differences in biological regulation: Predicting vulnerability to drug addiction, obesity, and other dysregulatory disorders.Experimental and clinical psychopharmacology · 2020Article
- The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience.International review of neurobiology · 2020Review
- The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine.Psychopharmacology · 2019Article
- Effects of opioids on the parental brain in health and disease.Frontiers in neuroendocrinology · 2019Review
- Defining Compulsive Behavior.Neuropsychology review · 2019Review
- Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats.Frontiers in molecular neuroscience · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesAddiction is defined as a chronically relapsing disorder characterized by compulsive drug seeking that is hypothesized to derive from multiple sources of motivational dysregulation. METHODS AND
resultsDr. Athina Markou made seminal contributions to our understanding of the neurobiology of addiction with her studies on the dysregulation of reward function using animal models with construct validity. Repeated overstimulation of the reward systems with drugs of abuse decreases reward function, characterized by brain stimulation reward and presumbably reflecting dysphoria-like states. The construct of negative reinforcement, defined as drug taking that alleviates a negative emotional state that is created by drug abstinence, is particularly relevant as a driving force in both the withdrawal/negative affect and preoccupation/anticipation stages of the addiction cycle.
conclusionsThe negative emotional state that drives such negative reinforcement is hypothesized to derive from the dysregulation of key neurochemical circuits that drive incentive-salience/reward systems (dopamine, opioid peptides) in the ventral striatum and from the recruitment of brain stress systems (corticotropin-releasing factor, dynorphin) within the extended amygdala. As drug taking becomes compulsive-like, the factors that motivate behavior are hypothesized to shift to drug-seeking behavior that is driven not only by positive reinforcement but also by negative reinforcement. This shift in motivation is hypothesized to reflect the allostatic misregulation of hedonic tone such that drug taking makes the hedonic negative emotional state worse during the process of seeking temporary relief with compulsive drug taking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.