Evidence map›Paper›PMID 28050364›Full record

ArticleJournal of clinical and diagnostic research : JCDR2016

Serological Diagnosis of Acute Scrub Typhus in Southern India: Evaluation of InBios Scrub Typhus Detect IgM Rapid Test and Comparison with other Serological Tests.

Velmurugan Anitharaj, Selvaraj Stephen, Jothimani Pradeep, Sungman Park, Seung-Han Kim, Young Jin Kim, Eun-Ye Kim, Yoon-Won Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  20. Scrub Typhus: An Acute Precipitant for Acute on Chronic Liver Failure.Journal of clinical and experimental hepatology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Velmurugan AnitharajPh.D. Scholar, Department of Microbiology, Mahatma Gandhi Medical College and Research Institute , Puducherry, India .
Selvaraj StephenProfessor, Department of Microbiology, Mahatma Gandhi Medical College and Research Institute , Puducherry, India .
Jothimani PradeepPh.D. Scholar, Department of Microbiology, Mahatma Gandhi Medical College and Research Institute , Puducherry, India .
Sungman ParkScientist, ImmuneMed Inc. , Chuncheon, Gangwon Do, South Korea .
Seung-Han KimScientist, ImmuneMed Inc. , Chuncheon, Gangwon Do, South Korea .
Young Jin KimScientist, ImmuneMed Inc. , Chuncheon, Gangwon Do, South Korea .
Eun-Ye KimScientist, ImmuneMed Inc. , Chuncheon, Gangwon Do, South Korea .
Yoon-Won KimTeaching Faculty, Department of Microbiology, Hallym University College of Medicine , Chuncheon, Gangwon do, South Korea .
Mahatma Gandhi Medical College and Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionScrub Typhus (ST) is being reported from different parts of India in the recent past. However, the diagnosis and confirmation of ST cases require specific serological and molecular diagnostic tests. Both rapid and conventional ELISA tests need to be properly evaluated.

aimEvaluation of a new ST IgM Immunochromatography (ICT) test kit (InBios Scrub Typhus Detect IgM Rapid Test) and compare it with another rapid kit, conventional ELISA kit and Weil-Felix (WF) test. MATERIALS AND

methodsThis prospective study was carried out in Mahatma Gandhi Medical College and Research Institute, Puducherry, during November 2015 to June 2016. Clinically suspected 220 ST patients were examined by a new kit, InBios Scrub Typhus Detect IgM Rapid Test, taking the conventional InBios Scrub Typhus Detect IgM ELISA as reference. Additional comparison was made with ImmuneMed Scrub Typhus Rapid, and WF test (single OXK titers ≥1:320). Statistical analysis was performed (Chi-square, Spearman's correlation and Kappa) using IBM SPSS Statistics 17 for Windows (SPSS Inc; Chicago, USA).

resultsPercentage Sensitivity, Specificity, Positive Predictive and Negative Predictive Values for InBios, ImmuneMed and WF were 99.25, 93.02, 95.68, 98.77; 94.87, 94.19, 96.21, 92.05 and 50.38, 95.51, 94.29, 56.67 respectively. A total of 134 patients were positive in reference standard InBios IgM ELISA.

conclusionThis new rapid ST IgM kit validated for the first time in India, showed good sensitivity and specificity. As a Point-of-Care (PoC) test, the kit would be helpful in both urban and remote rural parts of India.

Indexed as

Enzyme-linked immunosorbent assayImmunochromatographyOrientia tsutsugamushi

Identifiers

PMID28050364
PMCPMC5198317
OpenAlexW2559017507

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.