Evidence map›Paper›PMID 28050310›Full record

ReviewParkinson's disease2016

Gastrointestinal Dysfunctions in Parkinson's Disease: Symptoms and Treatments.

Andrée-Anne Poirier, Benoit Aubé, Mélissa Côté, Nicolas Morin, Thérèse Di Paolo, Denis Soulet

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Parkinson's disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Device aided therapies in Parkinson disease: an expert view on apomorphine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrée-Anne PoirierAxe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada; Faculty of Pharmacy, Laval University, Quebec City, QC, Canada.ORCID 0000-0003-3620-2694
Benoit AubéAxe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada.
Mélissa CôtéAxe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada; Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec City, QC, Canada.
Nicolas MorinFaculty of Medicine, Laval University, Quebec City, QC, Canada.
Thérèse Di PaoloAxe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada; Faculty of Pharmacy, Laval University, Quebec City, QC, Canada.
Denis SouletAxe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada; Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec City, QC, Canada.ORCID 0000-0002-0937-7061
Centre hospitalier universitaire de Québec · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A diagnosis of Parkinson's disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor. However, a growing body of evidence supports the hypothesis that nonmotor symptoms, especially gastrointestinal dysfunctions, could be considered as early biomarkers since they are ubiquitously found among confirmed patients and occur much earlier than their motor manifestations. According to Braak's hypothesis, the disease is postulated to originate in the intestine and then spread to the brain via the vagus nerve, a phenomenon that would involve other neuronal types than the well-established dopaminergic population. It has therefore been proposed that peripheral nondopaminergic impairments might precede the alteration of dopaminergic neurons in the central nervous system and, ultimately, the emergence of motor symptoms. Considering the growing interest in the gut-brain axis in Parkinson's disease, this review aims at providing a comprehensive picture of the multiple gastrointestinal features of the disease, along with the therapeutic approaches used to reduce their burden. Moreover, we highlight the importance of gastrointestinal symptoms with respect to the patients' responses towards medical treatments and discuss the various possible adverse interactions that can potentially occur, which are still poorly understood.

Identifiers

PMID28050310
PMCPMC5168460
OpenAlexW2560353112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.