Evidence map›Paper›PMID 28050226›Full record

ArticleOxidative medicine and cellular longevity2016

The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation- and Oxidative Stress-Induced Dysfunction of

Elisabetta Profumo, Brigitta Buttari, Daniela D'Arcangelo, Lavinia Tinaburri, Maria Antonietta Dettori, Davide Fabbri, Giovanna Delogu, Rachele Riganò

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

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  5. Targeted Delivery of Salusin-α Into Rabbit Carotid Arterial Endothelium Using SonoVue.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022
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  10. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elisabetta ProfumoDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-7261-8884
Brigitta ButtariDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-0575-4106
Daniela D'ArcangeloLaboratory of Vascular Pathology, Istituto Dermopatico Dell'Immacolata-IRCCS, Fondazione Luigi Maria Monti, Via Monti Creta 104, 00167 Rome, Italy.
Lavinia TinaburriDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Maria Antonietta DettoriIstituto di Chimica Biomolecolare, CNR, Traversa La Crucca 3, 07100 Sassari, Italy.
Davide FabbriIstituto di Chimica Biomolecolare, CNR, Traversa La Crucca 3, 07100 Sassari, Italy.
Giovanna DeloguIstituto di Chimica Biomolecolare, CNR, Traversa La Crucca 3, 07100 Sassari, Italy.
Rachele RiganòDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0003-3014-3523
Istituto Superiore di Sanità · ITIstituto di Chimica Biomolecolare · ITIstituto Dermopatico dell'Immacolata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is characterized by endothelial dysfunction, mainly induced by inflammation and oxidative stress. Increased reactive oxygen species (ROS) production together with increased adhesion molecules and thrombogenic tissue factor (TF) expression on endothelial cells has a key role in proatherogenic mechanisms. Therefore downmodulation of these molecules could be useful for reducing the severity of inflammation and atherosclerosis progression. Dehydrozingerone (DHZ) is a nutraceutical compound with anti-inflammatory and antioxidant activities. In this study we evaluated the ability of DHZ and its symmetric dimer to modulate hydrogen peroxide- (H

Indexed as

Dietary SupplementsDimerizationAtherosclerosisCell AdhesionCell SurvivalFluorometryGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsInflammationIntercellular Adhesion Molecule-1Intracellular SpaceNF-kappa BOxidative StressReactive Oxygen SpeciesSolubilityIntercellular Adhesion Molecule-1methyl-3-methoxy-4-hydroxystyryl ketoneNF-kappa BReactive Oxygen SpeciesStyrenesThromboplastinVascular Cell Adhesion Molecule-1

Identifiers

PMID28050226
PMCPMC5165227
OpenAlexW2560791667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.