ArticleThe Journal of veterinary medical science2017
Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic Regulation of Immune Response in Dogs.Genes · 2025Review
- Intestinal Biomarkers and Their Importance in Canine Enteropathies.Veterinary medicine international · 2024Review
- Clinical characteristics of dogs presenting with vomiting as a gastrointestinal sign of chronic enteropathy.Veterinary and animal science · 2022Article
- Expression of genes encoding interleukin 15 and its receptor subunits in the duodenal and colonic mucosae of dogs with chronic enteropathy.Veterinary and animal science · 2022Article
- Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy-A Search for Potential Biomarkers.Animals : an open access journal from MDPI · 2022Review
- Expression of genes encoding inflammasome sensor subunits in the duodenal and colonic mucosae of dogs with chronic enteropathy.The Journal of veterinary medical science · 2021Article
- Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil.The Journal of veterinary medical science · 2021Article
- Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies.Journal of veterinary internal medicine · 2021Article
- What are the potential biomarkers that should be considered in diagnosing and managing canine chronic inflammatory enteropathies?Open veterinary journal · 2021Review
- Interleukin-13 and interleukin-33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy.Journal of veterinary internal medicine · 2019Article
- Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs.Journal of veterinary internal medicine · 2018Review
- Effect of interleukin-1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease.Journal of veterinary internal medicine · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE.
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