Evidence map›Paper›PMID 28049849›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes.

Yvonne M C Kooy-Winkelaar, Dagmar Bouwer, George M C Janssen, Allan Thompson, Martijn H Brugman, Frederike Schmitz, Arnoud H de Ru, Tom van Gils, Gerd Bouma, Jon J van Rood and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  3. Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
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  18. Distinct phenotype of CD4Nature medicine · 2019
    Article
  19. Review
  20. Pathogenesis of Enteropathy-Associated T Cell Lymphoma.Current hematologic malignancy reports · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Yvonne M C Kooy-WinkelaarDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Dagmar BouwerDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
George M C JanssenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Allan ThompsonDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Martijn H BrugmanDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Frederike SchmitzDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Arnoud H de RuCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Tom van GilsDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam 1081 HZ, The Netherlands.
Gerd BoumaDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam 1081 HZ, The Netherlands.
Jon J van RoodDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands; vanrood@europdonor.nl J.van_Bergen@lumc.nl.
Peter A van VeelenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
M Luisa MearinDepartment of Pediatrics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Chris J MulderDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam 1081 HZ, The Netherlands.
Frits KoningDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Jeroen van BergenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands; vanrood@europdonor.nl J.van_Bergen@lumc.nl.
Leiden University Medical Center · NLAmsterdam UMC Location VUmc · NL

Funding

Worldwide Cancer Research 14-0245
6 · The paper itself

Abstract

Refractory celiac disease type II (RCDII) is a severe complication of celiac disease (CD) characterized by the presence of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classical B-, T-, and natural killer (NK)-cell lineage markers (Lin

Indexed as

ApoptosisCD4-Positive T-LymphocytesCeliac DiseaseCell ProliferationCells, CulturedCytokinesDrug SynergismDuodenumHumansInterleukin-15Interleukin-2Interleukin-21InterleukinsIntraepithelial LymphocytesRecombinant ProteinsTranscriptomeCytokinesInterleukin-15Interleukin-2Interleukin-21InterleukinsRecombinant ProteinsTumor Necrosis Factor-alphaceliac diseaseenteropathy-associated T-cell lymphomaintraepithelial lymphocyterefractory celiac diseasesmall-molecule inhibitor

Identifiers

PMID28049849
PMCPMC5307453
OpenAlexW2564720581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.