ArticleProceedings of the National Academy of Sciences of the United States of America2017
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed, 151 citations in OpenAlex.
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- Different Ferromanganese Concretion Morphologies Host Distinct Microbial Communities and Metal Accumulation Patterns in the Baltic Sea.Environmental microbiology · 2026Article
- Ammonia oxidation and recalcitrant carbon degradation fuel mixotrophic growth in the symbiont community of a deep-sea sponge.Microbiome · 2026Article
- MALDI-FISH for Colocalization of Brominated Metabolites andJournal of natural products · 2026Article
- Chemical richness and diversity of uncultivated 'Entotheonella' symbionts in marine sponges.Nature chemical biology · 2026Article
- New insights into the microbiome of the deep-sea spongeMicrobial genomics · 2026Article
- Ecological Prevalence and Non-Enzymatic Formation of Imidazolium Alkaloids on Moon Snail Egg Collars.Molecules (Basel, Switzerland) · 2026Article
- Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in MarineACS chemical biology · 2025Article
- Pilot Scale Production of a FBiotechnology journal · 2025Article
- Changes in microbiome composition during ontogeny and dispersal of the coral boring sponge Thoosa mismalolli.Scientific reports · 2025Article
- Autecology of an oscillating population of a novel host-associatedISME communications · 2025Article
- Excavation of resources ofFrontiers in microbiology · 2025Article
- Non-Canonical Cytochrome P450 Enzymes in Nature.bioRxiv : the preprint server for biology · 2024Article
- Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia.Marine drugs · 2024Review
- Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases.Journal of fungi (Basel, Switzerland) · 2024Article
- High compositional and functional similarity in the microbiome of deep-sea sponges.The ISME journal · 2024Article
- Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction.The ISME journal · 2024Article
- Oxalate and oxalotrophy: an environmental perspective.Sustainable microbiology · 2024Review
- Candidatus Nemesobacterales is a sponge-specific clade of the candidate phylum Desulfobacterota adapted to a symbiotic lifestyle.The ISME journal · 2023Article
- Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling.Nature protocols · 2023Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The as-yet uncultured filamentous bacteria "Candidatus Entotheonella factor" and "Candidatus Entotheonella gemina" live associated with the marine sponge Theonella swinhoei Y, the source of numerous unusual bioactive natural products. Belonging to the proposed candidate phylum "Tectomicrobia," Candidatus Entotheonella members are only distantly related to any cultivated organism. The Ca E. factor has been identified as the source of almost all polyketide and modified peptides families reported from the sponge host, and both Ca Entotheonella phylotypes contain numerous additional genes for as-yet unknown metabolites. Here, we provide insights into the biology of these remarkable bacteria using genomic, (meta)proteomic, and chemical methods. The data suggest a metabolic model of Ca Entotheonella as facultative anaerobic, organotrophic organisms with the ability to use methanol as an energy source. The symbionts appear to be auxotrophic for some vitamins, but have the potential to produce most amino acids as well as rare cofactors like coenzyme F
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