Evidence map›Paper›PMID 28049836›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes.

Zhen Song, Zhilin Qu, Alain Karma

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024
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  14. Order Through Disorder: The Characteristic Variability of Systems.Frontiers in cell and developmental biology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhen SongDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Zhilin QuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; a.karma@neu.edu zqu@mednet.ucla.edu.
Alain KarmaDepartment of Physics, Northeastern University, Boston, MA 02115; a.karma@neu.edu zqu@mednet.ucla.edu.
University of California, Los Angeles · USNortheastern University · US

Funding

A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the OrganR01HL110791 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2013 to 2017
$7.3M
Systems Modeling of Cardiac Excitation-Contraction-Metabolism CouplingR56HL118041 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2014 to 2014
$358k
NHLBI NIH HHS R01 HL110791NHLBI NIH HHS R56 HL118041
6 · The paper itself

Abstract

Cardiac myocytes normally initiate action potentials in response to a current stimulus that depolarizes the membrane above an excitation threshold. Aberrant excitation can also occur due to spontaneous calcium (Ca

Indexed as

Models, CardiovascularAction PotentialsAnimalsArrhythmias, CardiacCalcium SignalingComputer SimulationElectrophysiological PhenomenaFeedback, PhysiologicalHumansIon ChannelsMyocytes, CardiacStochastic ProcessesIon Channelsarrhythmiasbistabilitycalcium wavedelayed afterdepolarizationtriggered activity

Identifiers

PMID28049836
PMCPMC5255629
OpenAlexW2566117877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.