ArticleProceedings of the National Academy of Sciences of the United States of America2017
Antibiotic stress selects against cooperation in the pathogenic bacterium Pseudomonas aeruginosa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Ecological histories govern social exploitation by microorganisms.The ISME journal · 2025Article
- Cultivating antimicrobial resistance: how intensive agriculture ploughs the way for antibiotic resistance.Microbiology (Reading, England) · 2023Review
- Sub-Inhibitory Antibiotic Exposure and Virulence inAntibiotics (Basel, Switzerland) · 2021Review
- Loss of a pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion.The ISME journal · 2021Article
- Proteomic profiling of clinical and environmental strains of Pseudomonas aeruginosa.Molecular biology reports · 2021Article
- Positive interactions within and between populations decrease the likelihood of evolutionary rescue.PLoS computational biology · 2021Article
- Bacterial siderophores in community and host interactions.Nature reviews. Microbiology · 2020Review
- Genetic architecture constrains exploitation of siderophore cooperation in the bacteriumEvolution letters · 2019Article
- Transposable temperate phages promote the evolution of divergent social strategies inProceedings. Biological sciences · 2019Article
- Conditional privatization of a public siderophore enables Pseudomonas aeruginosa to resist cheater invasion.Nature communications · 2018Article
- Hotspot mutations and ColE1 plasmids contribute to the fitness of Salmonella Heidelberg in poultry litter.PloS one · 2018Article
- Quantitative and synthetic biology approaches to combat bacterial pathogens.Current opinion in biomedical engineering · 2017Article
- Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific.The ISME journal · 2017Article
- Inhibition of biofilm formation in Mycobacterium smegmatis by Parinari curatellifolia leaf extracts.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cheats are a pervasive threat to public goods production in natural and human communities, as they benefit from the commons without contributing to it. Although ecological antagonisms such as predation, parasitism, competition, and abiotic environmental stress play key roles in shaping population biology, it is unknown how such stresses generally affect the ability of cheats to undermine cooperation. We used theory and experiments to address this question in the pathogenic bacterium, Pseudomonas aeruginosa Although public goods producers were selected against in all populations, our competition experiments showed that antibiotics significantly increased the advantage of nonproducers. Moreover, the dominance of nonproducers in mixed cultures was associated with higher resistance to antibiotics than in either monoculture. Mathematical modeling indicates that accentuated costs to producer phenotypes underlie the observed patterns. Mathematical analysis further shows how these patterns should generalize to other taxa with public goods behaviors. Our findings suggest that explaining the maintenance of cooperative public goods behaviors in certain natural systems will be more challenging than previously thought. Our results also have specific implications for the control of pathogenic bacteria using antibiotics and for understanding natural bacterial ecosystems, where subinhibitory concentrations of antimicrobials frequently occur.
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