ArticleProceedings of the National Academy of Sciences of the United States of America2017
p53 pathway is involved in cell competition during mouse embryogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed.
- Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition.PLoS genetics · 2026Article
- The embryo game uncovers hidden cell behaviours.Nature communications · 2026Article
- Critical role of cell competition in gliomagenesis.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of cellular fitness and cell competition: Towards an integrated view.Current opinion in cell biology · 2025Review
- Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals.eLife · 2025Article
- Cell competition eliminates aneuploid human pluripotent stem cells.Stem cell reports · 2025Article
- Competitive signaling and cellular communications in myocardial infarction response.Molecular biology reports · 2025Review
- Human embryonic genetic mosaicism and its effects on development and disease.Nature reviews. Genetics · 2024Review
- P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition.PLoS genetics · 2024Article
- Mutation of p53 increases the competitive ability of pluripotent stem cells.Development (Cambridge, England) · 2024Article
- The Expression of Two Distinct Sets of Glycolytic Enzymes Reveals Differential Effects of Glycolytic Reprogramming on Pancreatic Ductal Tumorigenesis in Mice.Biomedicines · 2023Article
- Evolutionary determinants of curability in cancer.Nature ecology & evolution · 2023Review
- Homophilic interaction of cell adhesion molecule 3 coordinates retina neuroepithelial cell proliferation.The Journal of cell biology · 2023Article
- To not love thy neighbor: mechanisms of cell competition in stem cells and beyond.Cell death and differentiation · 2023Review
- Mdm2/p53 levels in bone marrow mesenchymal stromal cells is essential for maintaining the hematopoietic niche in response to DNA damage.Research square · 2023Article
- Cell competition in development, homeostasis and cancer.Nature reviews. Molecular cell biology · 2023Review
- Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors.Nature communications · 2022Article
- Human papillomavirus type 16 E6 induces cell competition.PLoS pathogens · 2022Article
- Article
- Mutant p53 in cell-cell interactions.Genes & development · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of tumor suppressor p53 has been under intense investigation. Acute stresses such as DNA damage are able to trigger a high level of p53 activity, leading to cell cycle arrest or apoptosis. In contrast, the cellular response of mild p53 activity induced by low-level stress in vivo remains largely unexplored. Murine double minute (MDM)2 and MDM4 are two major negative regulators of p53. Here, we used the strategy of haploinsufficiency of Mdm2 and Mdm4 to induce mild p53 activation in vivo and found that Mdm2
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